ANALYSIS OF LOCAL ANTIBODY-PRODUCTION IN THE VITREOUS-HUMOR OF PATIENTS WITH SEVERE UVEITIS

被引：30

作者：

BAARSMA, GS ^{[1
]}

LUYENDIJK, L ^{[1
]}

KIJLSTRA, A ^{[1
]}

DEVRIES, J ^{[1
]}

PEPERKAMP, E ^{[1
]}

MERTENS, DAE ^{[1
]}

VANMEURS, JC ^{[1
]}

机构：

[1] NETHERLANDS OPHTHALM RES INST,AMSTERDAM,NETHERLANDS

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 1991年 / 112卷 / 02期

关键词：

D O I：

10.1016/S0002-9394(14)76693-0

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We analyzed the local antibody production in vitreous humor samples collected during vitrectomy in patients with severe vision-threatening uveitis. In 24 patients, paired serum and undiluted vitreous humor samples were collected and tested for antibodies against Toxoplasma gondii, herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, and Toxocara canis. Total IgG and the Goldmann-Witmer coefficient were determined. The initial diagnosis of ocular toxoplasmosis could be confirmed in six of the seven patients. The seventh patient showed a local antibody production against herpes simplex virus. One of the three patients with chronic panuveitis at initial diagnosis showed a local antibody production against T. gondii. These last two findings resulted in a change in medical treatment. Analysis of local antibody production in vitreous humor samples is a valuable diagnostic tool.

引用

页码：147 / 150

页数：4

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