A PROSPECTIVE, DOUBLE-BLIND-STUDY OF METOCLOPRAMIDE HYDROCHLORIDE FOR THE CONTROL OF MIGRAINE IN THE EMERGENCY DEPARTMENT

被引：98

作者：

TEK, DS ^{[1
]}

MCCLELLAN, DS ^{[1
]}

OLSHAKER, JS ^{[1
]}

ALLEN, CL ^{[1
]}

ARTHUR, DC ^{[1
]}

机构：

[1] USN HOSP,DEPT CLIN INVEST,SAN DIEGO,CA 92134

来源：

ANNALS OF EMERGENCY MEDICINE | 1990年 / 19卷 / 10期

关键词：

metoclopramide hydrochloride; migraine;

D O I：

10.1016/S0196-0644(05)81508-2

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Study objective: To determine the effectiveness of IV metoclopramide as sole therapy for relieving the pain of acute migraine in the emergency department. Design: Prospective study. Fifty patients were divided randomly into subjects and placebo controls with blinding of the treating physician and the patient. Participants: Patients presenting to the ED with migraine requiring parenteral treatment. Interventions: Subjects received 10 mg IV metoclopramide and controls received IV normal saline; patient assessment of relief was followed by means of a numerical scale. Measurements and main results: Sixty-seven percent of subjects compared with 19% of controls had effective pain relief within one hour (P < .001). Subjects achieved mean relief scores of 2.46 compared with 1.69 for controls (P < .02). No significant side effects were observed. Conclusion: IV metoclopramide as a single agent is effective and safe therapy for migraine in the ED. © 1990 American College of Emergency Physicians.

引用

页码：1083 / 1087

页数：5

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