INTRACELLULAR DCTP/ARA-CTP RATIO AND THE CYTOTOXIC EFFECT OF ARA-C

被引：9

作者：

KAWASAKI, H ^{[1
]}

KUWABARA, H ^{[1
]}

HORI, H ^{[1
]}

HIGASHIGAWA, M ^{[1
]}

OHKUBO, T ^{[1
]}

SAKURAI, M ^{[1
]}

机构：

[1] MIE UNIV,SCH MED,TUMOR CLIN RES CTR,TSU,MIE 514,JAPAN

来源：

CANCER INVESTIGATION | 1991年 / 9卷 / 04期

关键词：

D O I：

10.3109/07357909109084638

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study, the relationship between the dCTP/ara-CTP ratio and the cytotoxic effect of cytosine arabinoside (ara-C) was investigated. Intracellular levels of dNTPs and ara-CTP were analyzed by high-performance liquid chromatography. Although doubling time and intracellular dCTP levels were different in each of the cells, there was a consistent relation between the intracellular dCTP/ara-CTP ratio and the cytotoxic concentration of ara-C. These data suggest that the intracellular dCTP/ara-CTP ratio is one of the important factors for considering the cytotoxic action of ara-C.

引用

页码：409 / 413

页数：5

共 17 条

[1] DOSE-RELATED SYNERGISM OF CYTOSINE-ARABINOSIDE AND METHOTREXATE AGAINST MURINE LEUKEMIA-L1210 [J].

AVERY, TL ;

ROBERTS, D .

EUROPEAN JOURNAL OF CANCER, 1974, 10 (07) :425-429

[2]

BERTINO JR, 1981, CANCER TREAT REP, V65, P131

[3]

CADMAN E, 1981, J CLIN INVEST, V64, P788

[4]

HIGASHIGAWA M, 1989, MED ONCOL TUMOR PHAM, V5, P265

[5] SYNERGISTIC AND ANTAGONISTIC INTERACTIONS OF METHOTREXATE AND 1-BETA-D-ARABINOFURANOSYLCYTOSINE IN HEPATOMA-CELLS - THE MODULATING EFFECT OF PURINES [J].

JACKSON, RC ;

HARKRADER, RJ .

BIOCHEMICAL PHARMACOLOGY, 1981, 30 (03) :223-229

[6]

KAWASAKI H, 1985, JPN J CANCER CHEMOTH, V12, P815

[7]

KAWASAKI H, 1986, IGAKUNOAYUMI, V137, P1019

[8]

KHYM JX, 1975, CLIN CHEM, V21, P124

[9]

KUFE D, 1984, BLOOD, V64, P54

[10]

KUFE DW, 1984, MOL PHARMACOL, V26, P128

← 1 2 →