ANTHRACYCLINE METABOLITES FROM STREPTOMYCES-VIOLACEUS A262 .1. ISOLATION OF ANTIBIOTIC-BLOCKED MUTANTS FROM STREPTOMYCES-VIOLACEUS A262

被引：24

作者：

JOHDO, O ^{[1
]}

ISHIKURA, T ^{[1
]}

YOSHIMOTO, A ^{[1
]}

TAKEUCHI, T ^{[1
]}

机构：

[1] INST MICROBIAL CHEM,SHINAGAWA KU,TOKYO 141,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 10期

关键词：

D O I：

10.7164/antibiotics.44.1110

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Five mutant (or variant) strains producing new anthracycline antibiotics were derived from Streptomyces violaceus A262 by mutagenesis treatment. Strain SE1-625 showed a limited production of three known beta-rhodomycinone diglycosides while the parent strain produced numerous unidentified beta-rhodomycinone glycosides. Strain SU2-730 was an antibiotic-blocked mutant which produced only epsilon-rhodomycinone glycosides (named epelmycins). Strains SC-7 and SE2-2385 were variants which produced alpha-citromycinone glycosides (named yellamycins) and beta-isorhodomycinone glycosides (named obelmycins), respectively. Strain SE2-2385-Al produced alpha-2-rhodomycinone glycosides. (named alldimycins). Glycosidation-less mutants which accumulated only aglycone were also obtained. Isolation of these mutants or variants and preliminary identification of their anthracycline products are described.

引用

页码：1110 / 1120

页数：11

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