ANCHORING OF FMOC AMINO-ACID TO 4-ALKOXYBENZYL ALCOHOL RESIN USING A NEW ESTERIFICATION REAGENT

被引：36

作者：

AKAJI, K ^{[1
]}

KURIYAMA, N ^{[1
]}

KIMURA, T ^{[1
]}

FUJIWARA, Y ^{[1
]}

KISO, Y ^{[1
]}

机构：

[1] KYOTO PHARMACEUT UNIV,DEPT MED CHEM,YAMASHINA KU,KYOTO 607,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)79845-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Esterification of Fmoc (fluoren-9-ylmethyloxycarbonyl) amino acid or amino acid derivative to 4-alkoxybenzylalcohol resin was achieved in generally good yield using a new esterification reagent, CIP [2-chloro-1,3-dimethylimidazolidinium hexafluorophosphate] or BOI [2-(benzotriazol-1-yl) oxy-1,3-dimethylimidazolidinium hexafluorophosphate]. The reaction was rapider with the same or lower racemization level than the anchoring reaction using the conventional esterification reagents.

引用

页码：3177 / 3180

页数：4

共 16 条

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