EFFECTS OF AMLODIPINE ON CIRCADIAN-RHYTHMS IN BLOOD-PRESSURE, HEART-RATE, AND MOTILITY - A TELEMETRIC STUDY IN RATS

被引：34

作者：

MATTES, A ^{[1
]}

LEMMER, B ^{[1
]}

机构：

[1] UNIV FRANKFURT,ZENTRUM PHARMAKOL,THEODOR STERN KAI 7,W-6000 FRANKFURT 1,GERMANY

来源：

CHRONOBIOLOGY INTERNATIONAL | 1991年 / 8卷 / 06期

关键词：

CIRCADIAN RHYTHM; RAT; AMLODIPINE; BLOOD PRESSURE AND HEART RATE; MOTOR ACTIVITY; DOSE-RESPONSE RELATIONSHIP;

D O I：

10.3109/07420529109059188

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In male Wistar rats [light (L): 07:00-19:00 h, dark (D): 19:00-07:00 h], the effects of the calcium channel blocker amlodipine (1, 3, 10 mg/kg i.p.) on blood pressure, heart rate, and motor activity were studied by telemetric monitoring. Amlodipine was injected either at 07:00 h or at 19:00 h. Systolic and diastolic blood pressure were dose-dependently decreased with more pronounced effects in the dark span, ED50 values in D were about seven times lower than in L. In contrast, the dose-dependent increase in heart rate was more pronounced in L than in D. No significant effects of amlodipine were found on motor activity. The study gives evidence for a circadian phase-dependency in the cardiovascular effects amlodipine in rats.

引用

页码：526 / 538

页数：13

共 21 条

[1]

Murdoch D., Heel R.C., Amlodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cardiovascular desease, Drugs, 41, pp. 478-505, (1991)

[2]

Mroczek W.J., Burris J.F., Allenby K.S., Effect of amlodipine on 24-hour ambulatory blood pressure in hypertensive patients, J Cardiovasc Pharmacol, 17, pp. S 13-S 15, (1991)

[3]

Raftery E.B., Heber M.E., Brigden G., Al-Khawaja I., 24-hour blood pressure control with the once-daily calcium antagonist amlodipine, J Cardiovasc Pharmacol, 17, pp. S8-12, (1991)

[4]

Gould B.A., Hornung R.S., Mann S., Balasubramanian V., Raftery E.B., Slow channel inhibitors verapamil and nifedipine in the management of hypertension, J Cardiovasc Pharmacol, 4, pp. 5369-5373, (1982)

[5]

White W.B., Smith V.E., McCabe E.J., Meeran M.K., Effects of chronic nitrendipine on casual (office) and 24-h ambulatory blood pressure, Clin Pharmacol Ther, 38, pp. 60-64, (1985)

[6]

Lemmer B., Nold G., Kaiser R., Sustained-release nifedipine in hypertensives: 24-h-monitoring of blood pressure, heart rate, pharmacokinetics and plasma cAMP, Naunyn Schmiedebergs Arch Pharmacol, 343, (1991)

[7]

Lemmer B., Behne S., Becker H.J., Chronopharmacology of oral nifedipine in healthy subjects, Eur J Clin Pharmacol, 36, (1989)

[8]

Lemmer B., Nold G., Behne S., Becker H.J., Liefhold J., Kaiser R., Chronopharmacology of oral nifedipine in healthy subjects and hypertensive patients, Eur J Pharmacol, 183, (1990)

[9]

Lemmer B., Scheidel B., Behne S., Chronopharmacokinetics and chronopharmacodynamics of cardiovascular active drugs: propranolol, organic nitrates, nifedipine, Ann NY Acad Sci, 618, pp. 166-181, (1991)

[10]

Mattes A., Witte K., Hohmann W., Lemmer B., PHARMFIT–a non-linear fitting program for pharmacology, Chronobiol Inl, 8, pp. 460-476, (1991)

← 1 2 3 →