A SIMPLIFIED EXPERIMENTAL-DESIGN APPROACH TO OPTIMIZATION OF SFE CONDITIONS FOR EXTRACTION OF AN AMINE HYDROCHLORIDE

被引：22

作者：

BICKING, MKL

机构：

[1] TCT Corporation, St. Paul, MN, 55114-1776

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1992年 / 30卷 / 09期

关键词：

D O I：

10.1093/chromsci/30.9.358

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A two-level, two-factor (22) factorial design approach is used to optimize supercritical fluid extraction (SFE) conditions for the determination of an amine hydrochloride in avian feed. The recovery is maximized by optimizing the temperature and pressure. Maximum recovery is obtained at low temperature and high pressure. These conditions also provide a lower level of nonvolatile extractables. The optimized method demonstrates excellent recovery at levels as low as 5μg/g. © Oxford University Press 1992.

引用

页码：358 / 360

页数：3

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