SEPARATION OF THE ENANTIOMERS OF SOME POTASSIUM CHANNEL ACTIVATORS USING AN ALPHA-1-ACID GLYCOPROTEIN COLUMN

被引：5

作者：

EVANS, JM ^{[1
]}

SMITH, RJ ^{[1
]}

STEMP, G ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,PINNACLES,COLDHARBOUR RD,HARLOW CM19 5AD,ESSEX,ENGLAND

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 623卷 / 01期

关键词：

D O I：

10.1016/0021-9673(92)85312-H

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The separations of the enantiomers of some 3,4-dihydro-2,2'-dimethyl-2H-1-benzopyrans and a related tetrahydronaphthalene on alpha1-acid glycoprotein (Chiral-AGP) are presented, together with the results from an investigation of the effects of organic modifier and pH on the separations achieved. The general utility of Chiral-AGP in separating the enantiomers of compounds from this class of antihypertensive agents is demonstrated in this paper.

引用

页码：163 / 167

页数：5

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