DETERMINATION OF 1,4-BENZODIAZEPINES AND 1,5-BENZODIAZEPINES IN URINE USING A COMPUTERIZED GAS CHROMATOGRAPHIC-MASS SPECTROMETRIC TECHNIQUE

被引：47

作者：

MAURER, H ^{[1
]}

PFLEGER, K ^{[1
]}

机构：

[1] UNIV SAARLAND, INST PHARMAKOL & TOKIKOL, D-6650 HOMBURG, FED REP GER

来源：

JOURNAL OF CHROMATOGRAPHY | 1981年 / 222卷 / 03期

关键词：

D O I：

10.1016/S0378-4347(00)84141-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A clinical and forensic toxicological method for the determination of benzodiazepines and their main metabolites in human urine after acid hydrolysis is described. The extract is analyzed by computerized gas chromatography-mass spectrometry. An on-line computer allows rapid detection using mass fragmentography with the masses m/e 211, 230, 241, 244, 249, 262, 276 and 285. The mass fragmentogram and the underlying mass spectra of the hydrolysis products (benzophenones and analogs) are documented.

引用

页码：409 / 419

页数：11

共 6 条

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[5] MAURER H, UNPUBLISHED
[6] GLC-DATA OF 19 HYDROLYSIS-DERIVATIVES RISED FROM 12 IMPORTANT BENZODIAZEPINES AND 17 MAIN-METABOLITES
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