COMBRETATROPONES - HYBRIDS OF COMBRETASTATIN AND COLCHICINE - SYNTHESIS AND BIOCHEMICAL EVALUATION

被引：18

作者：

ANDRES, CJ

BERNARDO, JE

YAN, Q

HASTIE, SB

MACDONALD, TL

机构：

[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901

[2] SUNY BINGHAMTON,DEPT CHEM,BINGHAMTON,NY 13901

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81230-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological evaluation is presented for a new class of tubulin-targeting agents, termed ''combretatropones,'' that incorporate the 1,2-diaryl ethane nucleus of combretastatin and the tropone moiety of colchicine.

引用

页码：565 / 570

页数：6

共 16 条

[1] BANE S, 1984, J BIOL CHEM, V259, P7391
[2] BANWELL MG, 1991, AUST J CHEM, V44, P31
[3] PROMOTION OF FLUORESCENCE UPON BINDING OF COLCHICINE TO TUBULIN
BHATTACH.B
WOLFF, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (07) : 2627 - 2631
[4] Boye O., 1992, ALKALOIDS, V41, P125, DOI [10.1016/S0099-9598(08)60106-6, DOI 10.1016/S0099-9598(08)60106-6]
[5] COLCHICINE AND ITS ANALOGS - RECENT FINDINGS
BROSSI, A
YEH, HJC
CHRZANOWSKA, M
WOLFF, J
HAMEL, E
LIN, CM
QUIN, F
SUFFNESS, M
SILVERTON, J
[J]. MEDICINAL RESEARCH REVIEWS, 1988, 8 (01) : 77 - 94
[6] Capraro H.G., 1984, ALKALOIDS, V23, P1
[7] SYNTHESIS OF ALKOXY-SUBSTITUTED DIARYL COMPOUNDS AND CORRELATION OF RING SEPARATION WITH INHIBITION OF TUBULIN POLYMERIZATION - DIFFERENTIAL ENHANCEMENT OF INHIBITORY EFFECTS UNDER SUBOPTIMAL POLYMERIZATION REACTION CONDITIONS
GETAHUN, Z
JURD, L
CHU, PS
LIN, CM
HAMEL, E
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (06) : 1058 - 1067
[8] HAMEL E, 1982, BIOCHEM PHARMACOL, V32, P3864
[9] HASTIE SB, 1989, J BIOL CHEM, V264, P6682
[10] HASTIE SB, 1991, PHARMACOL THERAPEUT, V51, P379

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