COMBRETATROPONES - HYBRIDS OF COMBRETASTATIN AND COLCHICINE - SYNTHESIS AND BIOCHEMICAL EVALUATION

被引:18
作者
ANDRES, CJ
BERNARDO, JE
YAN, Q
HASTIE, SB
MACDONALD, TL
机构
[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901
[2] SUNY BINGHAMTON,DEPT CHEM,BINGHAMTON,NY 13901
关键词
D O I
10.1016/S0960-894X(01)81230-0
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The synthesis and biological evaluation is presented for a new class of tubulin-targeting agents, termed ''combretatropones,'' that incorporate the 1,2-diaryl ethane nucleus of combretastatin and the tropone moiety of colchicine.
引用
收藏
页码:565 / 570
页数:6
相关论文
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