RELATIONSHIP BETWEEN CATHEPSIN-D AND OTHER PATHOLOGICAL AND BIOLOGICAL PARAMETERS IN 1752 PATIENTS WITH PRIMARY BREAST-CANCER

被引：32

作者：

GION, M

MIONE, R

DITTADI, R

ROMANELLI, M

PAPPAGALLO, L

CAPITANIO, G

FRIEDE, U

BARBAZZA, R

VISONA, A

DANTE, S

机构：

[1] OSPED PF CALVI,CTR ONCOL,NOALE,ITALY

[2] OSPED CIVILE,SERV ANAT PATOL,VENICE,ITALY

[3] OSPED UMBERTO 1,SERV ANAT PATOL,MESTRE,ITALY

[4] OSPED CIVILE,SERV ANAT PATOL,MIRANO,ITALY

[5] OSPED BOLDRINI,SERV ANAT PATOL,THIENE,ITALY

[6] OSPED S BORTOLO,DIV ANAT PATOL,VICENZA,ITALY

来源：

EUROPEAN JOURNAL OF CANCER | 1995年 / 31A卷 / 05期

关键词：

CATHEPSIN D; BREAST CANCER; NODAL STATUS; TUMOR SIZE; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; PROGNOSIS;

D O I：

10.1016/0959-8049(94)00532-A

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The relationship between cathepsin D and other pathological or biological prognostic parameters has not yet been defined through systematic studies in breast cancer. The aim of the present investigation was to define the relationship between cathepsin D and nodal status, tumour size, steroid receptors and tumour grade in a wide patient series. Cytosol cathepsin D was assayed with an immunoradiometric assay in tumour samples from 1752 patients. A statistically significant, but not biologically meaningful association was found between cathepsin D and both tumour size and grade. Cathepsin D was significantly higher in node-positive than in node-negative tumours. However, cathepsin D is not of great use in order to predict the risk of axillary metastases in individual patients, due to overlapping of cathepsin D values between node-positive and node-negative cases. A significant, direct association was found between cathepsin D and both oestrogen receptor and progesterone receptor cytosol levels. Nevertheless, preliminary data indicate that cathepsin D and steroid receptors provide independent prognostic information.

引用

页码：671 / 677

页数：7

共 34 条

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