AEROSOLIZED SURFACTANT TREATMENT OF PRETERM LAMBS

被引:92
作者
LEWIS, JF [1 ]
IKEGAMI, M [1 ]
JOBE, AH [1 ]
TABOR, B [1 ]
机构
[1] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT PEDIAT,DIV NEONATOL,TORRANCE,CA 90509
关键词
NEBULIZATION; RESPIRATORY DISTRESS SYNDROME; SURFACTANT DISTRIBUTION; PHOSPHATIDYLCHOLINE;
D O I
10.1152/jappl.1991.70.2.869
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To evaluate the potential for aerosolized surfactant treatments of surfactant deficiency, twin lamb fetuses were delivered at 130-132 days gestational age and received nebulized natural surfactant (Neb NS), nebulized Survanta (Neb Surv), tracheally instilled natural surfactant (Inst NS), or nebulized saline (Neb Saline). Neb NS and Neb Surv groups had significant increases in ventilatory efficiency index and dynamic compliance values (P < 0.05). Both groups also had pressure-volume curves that were comparable to the Inst NS group. The Neb Saline control group had deterioration of the ventilation efficiency index and dynamic compliance values over time as well as pressure-volume curves that demonstrated smaller lung volumes compared with all three surfactant-treated groups (P < 0.01). Delivery of aerosolized surfactant to the lung was only approximately 2 mg lipid/kg for the nebulized groups, a dose one-twentieth of that previously noted to be effective in instillation protocols. Distribution histograms of the aerosolized surfactant-treated groups differed from the instilled animals as there was more deposition in the right upper lobes and tracheae in the nebulized groups compared with the instilled group (P < 0.05). Pulmonary blood flow was not altered by aerosolized surfactant treatment. Administration of aerosolized surfactant to preterm lambs improved lung function at a very low surfactant dose.
引用
收藏
页码:869 / 876
页数:8
相关论文
共 35 条
  • [1] LIPOSOME DISPOSITION INVIVO .6. DELIVERY TO THE LUNG
    ABRA, RM
    HUNT, CA
    LAU, DT
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1984, 73 (02) : 203 - 206
  • [2] BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
  • [3] PULMONARY DISTRIBUTION OF PARTICLES GIVEN BY INTRATRACHEAL INSTILLATION OR BY AEROSOL INHALATION
    BRAIN, JD
    KNUDSON, DE
    SOROKIN, SP
    DAVIS, MA
    [J]. ENVIRONMENTAL RESEARCH, 1976, 11 (01) : 13 - 33
  • [4] CHU J, 1967, PEDIATRICS, V40, P709
  • [5] CLYMAN RI, 1982, J PEDIATR-US, V100, P101
  • [6] FLAVIN M, 1986, PEDIATR PULM, V2, P36
  • [7] FUJIWARA T, 1980, LANCET, V1, P55
  • [8] EFFECT OF VOLUME AND DOSE ON THE PULMONARY DISTRIBUTION OF EXOGENOUS SURFACTANT ADMINISTERED TO NORMAL RABBITS OR TO RABBITS WITH OLEIC-ACID LUNG INJURY
    GILLIARD, N
    RICHMAN, PM
    MERRITT, TA
    SPRAGG, RG
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (03): : 743 - 747
  • [9] BLOOD-FLOW MEASUREMENTS WITH RADIONUCLIDE-LABELED PARTICLES
    HEYMANN, MA
    PAYNE, BD
    HOFFMAN, JIE
    RUDOLPH, AM
    [J]. PROGRESS IN CARDIOVASCULAR DISEASES, 1977, 20 (01) : 55 - 79
  • [10] RELATIONSHIP BETWEEN ALVEOLAR SATURATED PHOSPHATIDYLCHOLINE POOL SIZES AND COMPLIANCE OF PRETERM RABBIT LUNGS - THE EFFECT OF MATERNAL CORTICOSTEROID TREATMENT
    IKEGAMI, M
    JOBE, AH
    YAMADA, T
    SEIDNER, S
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 139 (02): : 367 - 369