SPONTANEOUS FRA16B IS A HOT-SPOT FOR SISTER CHROMATID EXCHANGES

被引：11

作者：

LUKUSA, T ^{[1
]}

MEULEPAS, E ^{[1
]}

FRYNS, JP ^{[1
]}

VANDENBERGHE, H ^{[1
]}

CASSIMAN, JJ ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,CTR HUMAN GENET,CAMPUS GASTHUISBERG,HERESTR 49,B-3000 LOUVAIN,BELGIUM

来源：

HUMAN GENETICS | 1991年 / 87卷 / 05期

关键词：

D O I：

10.1007/BF00209017

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Six heterozygous carriers of a fragile site at 16q22 were available for the current study. We demonstrated that the observed fragile site was a "BrdUrd-sensitive" fra(16)(q22) or FRA16B, capable of spontaneous expression in some individuals (= "spontaneous" FRA16B). Significant differences either in spontaneous or in ethylmethane sulfonate (EMS)-induced sister chromatid exchange (SCE) frequencies were found between the fragile 16q22 site, whether expressed or not, and its homologous normal site. These data complement our previous findings on FRAXA and provide additional arguments indicating that fragility and SCE are variable cytogenetic expressions of the same DNA structural alteration.

引用

页码：583 / 586

页数：4

共 22 条

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