CHARACTERISTICS OF ALPHA-ADRENOCEPTORS IN 2 HUMAN COLORECTAL-CANCER CELL-LINES

被引:4
作者
AGRAWAL, DK
WILDRICK, DM
BOMAN, BM
机构
[1] CREIGHTON UNIV,SCH MED,DEPT INTERNAL MED,24TH & CALIF ST,OMAHA,NE 68178
[2] CREIGHTON UNIV,SCH MED,CREIGHTON CANC CTR,OMAHA,NE 68178
关键词
D O I
10.1016/S0006-291X(05)80972-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The DiFi and HT-29 human colorectal cancer cell lines were characterized and compared with respect to binding properties of alpha adrenoceptors present on the cell surface. Both cell lines possessed alpha-1 and alpha-2 adrenoceptors of high affinity; however, DiFi cells were rich in alpha-1 adrenoceptors, whereas HT-29 cells were rich in alpha-2 adrenoceptors. In each cell line, specificity of radioligand binding to alpha-1 or alpha-2 adrenoceptors was proved via competition studies using non-tritiated drugs. We believe this to be the first characterization of alpha-1 adrenoceptors in cell line HT-29 and of alpha-1 and alpha-2 adrenoceptors in DiFi cells. Differences between these cell lines in alpha adrenoceptor expression are discussed in relation to colon carcinogenesis. The high level of alpha-1 adrenoceptors seen in DiFi cells should make this cell line useful in studies of the function and regulation of this adrenoceptor subtype. © 1992 Academic Press, Inc.
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页码:176 / 184
页数:9
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