INDUCTION OF CHROMOSOMAL-ABERRATIONS IN CULTURED MAMMALIAN-CELLS BY NICKEL COMPOUNDS

被引：83

作者：

NISHIMURA, M ^{[1
]}

UMEDA, M ^{[1
]}

机构：

[1] TOYOBO CO LTD,DIV CHEM PROD,KITA KU,OSAKA 530,JAPAN

来源：

MUTATION RESEARCH | 1979年 / 68卷 / 04期

关键词：

D O I：

10.1016/0165-1218(79)90166-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The effects of 4 Ni compounds, nickel chloride, nickel acetate, potassium cyanonickelate, and nickel sulfide were studied in a line of mammary carcinoma cells from the C3H mouse. All 4 were easily taken up by the cells and reacted with protein, RNA, and possibly DNA. Measurements of leucine, uridine, and thymidine uptake during exposure showed that the syntheses of protein and DNA were more sensitive than RNA. Chromosomal aberrations were observed during the recovery period following the end of the treatment with Ni. The implications of these results were discussed with respect to the carcinogenicity of the compounds and to the recommended protocols for mutagenicity testing by chromosomal aberrations. © 1979.

引用

页码：337 / 349

页数：13

共 12 条

[1] DIE VERTEILUNG VON FRAGMENTATIONEN UND ACHROMATISCHEN STELLEN AUF DEN CHROMOSOMEN VON VICIA FABA NACH BEHANDLUNG MIT SCHWERMETALLSALZEN
GLASS, E
[J]. CHROMOSOMA, 1956, 8 (03) : 260 - 284
[2] Glass E., 1955, Zeitschrift fur Botanik, V43, P359
[3] CYTOGENETIC ASSAYS OF CHEMICAL CLASTOGENS USING MAMMALIAN-CELLS IN CULTURE
HSU, TC
COLLIE, CJ
LUSBY, AF
JOHNSTON, DA
[J]. MUTATION RESEARCH, 1977, 45 (02): : 233 - 247
[4] KANEMATSU K, 1978, MUTAT RES, V53, P207, DOI 10.1016/0165-1161(78)90252-2
[5] EFFECT OF COBALT, NICKEL AND IRON ON MITOSIS IN ROOTS OF BROAD BEAN (VICIA FABA)
KOMCZYNSKI, L
REJNIAK, L
NOWAK, H
[J]. NATURE, 1963, 198 (488) : 1016 - &
[6] PROCEDURE FOR ISOLATION OF DEOXYRIBONUCLEIC ACID FROM MICRO-ORGANISMS
MARMUR, J
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1961, 3 (02) : 208 - &
[7] EFFECT OF METAL-CATIONS ON MIS-INCORPORATION BY ESCHERICHIA-COLI DNA-POLYMERASES
MIYAKI, M
MURATA, I
OSABE, M
ONO, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 77 (03) : 854 - 860
[8] MUTAGENIC ACTIVITIES OF METAL-COMPOUNDS IN BACTERIA
NISHIOKA, H
[J]. MUTATION RESEARCH, 1975, 31 (03): : 185 - 189
[9] OYAMA VI, 1956, P SOC EXP BIOL MED, V91, P305, DOI 10.3181/00379727-91-22245
[10] METAL-INDUCED INFIDELITY DURING DNA-SYNTHESIS
SIROVER, MA
LOEB, LA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (07) : 2331 - 2335

← 1 2 →