INTRACELLULAR-TRANSPORT OF MHC CLASS-II MOLECULES

被引：194

作者：

NEEFJES, JJ

PLOEGH, HL

机构：

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 05期

关键词：

D O I：

10.1016/0167-5699(92)90123-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MHC class II molecules associate, during biosynthesis, with peptides derived from endocytosed antigen. Here, Jacques Neefies and Hidde Ploegh describe the intracellular transport of MHC class II molecules and its relationship to the binding of peptides in endosomal compartments. They discuss alternative routes for the delivery of antigen to sites at which peptides associate with MHC class II molecules and raise the possibility of cell type-specific differences in the handling of MHC class II molecules, and hence in antigen presentation.

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页码：179 / 184

页数：6

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