EFFECT OF LOVASTATIN ON CHOLESTEROL ABSORPTION IN CHOLESTEROL-FED RABBITS

被引：18

作者：

NIELSEN, LB ^{[1
]}

STENDER, S ^{[1
]}

KJELDSEN, K ^{[1
]}

机构：

[1] ROSKILDE CTY HOSP,DEPT CLIN CHEM,KOGE,DENMARK

来源：

PHARMACOLOGY & TOXICOLOGY | 1993年 / 72卷 / 03期

关键词：

D O I：

10.1111/j.1600-0773.1993.tb00307.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the present study was to investigate the effect of the hydroxymethylglutaryl (HMG)-CoA reductase inhibitor lovastatin on some aspects of cholesterol metabolism in cholesterol-fed rabbits. The plasma cholesterol concentration was markedly lower in lovastatin-treated rabbits (6 mg/rabbit/day) compared to controls after 36 days of cholesterol-feeding (x+/-S.E.) (19+/-4 mmol/l, n=9 versus 153+/-17 mmol/l, n=7) (P<0.00001). Intestinal absorption of cholesterol in such rabbits was reduced by 15% in lovastatin-treated rabbits (n=21) compared to controls (n=18) (P<0.025). The results suggest that the hypocholesterolaemic effect of lovastatin in cholesterol-fed rabbits is associated with a decreased intestinal absorption of cholesterol.

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页码：148 / 151

页数：4

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