INHIBITION OF TRANSIENT OUTWARD CURRENT BY INTRACELLULAR ION SUBSTITUTION UNMASKS SLOW INWARD CALCIUM CURRENT IN CARDIAC PURKINJE-FIBERS

被引：23

作者：

MARBAN, E ^{[1
]}

机构：

[1] YALE UNIV, DEPT PHYSIOL, NEW HAVEN, CT 06510 USA

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1981年 / 390卷 / 01期

关键词：

D O I：

10.1007/BF00582721

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The ionophore nystatin was used to replace intracellular K+ with Cs+ in calf Purkinje fibers. Such replacement inhibited the transient outward current, and unmasked a large slow inward current (Isi). The involvement of K+ as a charge carrier of the transient outward current is supported and a method for better analysis of Isi is suggested.

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页码：102 / 106

页数：5

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