AUGMENTATION OF PRESSOR RESPONSE TO OCTAPRESSIN BY AUTONOMIC BLOCKING AGENTS IN PITHED RAT

被引：8

作者：

LEENEN, FHH

DEJONG, W

机构：

[1] Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Utrecht

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1969年 / 6卷 / 01期

关键词：

autonomic blocking agents; blood pressure response; norepinephrine-infusion; octapressin; peripheral vascular effects; pithed rat;

D O I：

10.1016/0014-2999(69)90063-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of octapressin on blood pressure was studied in anesthetized pithed male rats, pretreated with autonomic blocking agents. Phenoxybenzamine and chlorpromazine induced an augmentation of the blood pressure response to octapressin, whereas atropine, propranolol and hexamethonium had no effect on the response to octapresin in the pithed rat. It is concluded that phenoxybenzamine and chlorpromazine augment the blood pressure response to octapressin in the pithed rat by a direct effect on the peripheral vascular effector cells. © 1969.

引用

页码：45 / +

页数：1

共 12 条

[1] EVALUATION OF NEUROHUMORAL SUBSTANCES IN LOCAL REGULATION OF BLOOD FLOW [J].