PHOTOLYTIC DECOMPOSITION OF INDAPAMIDE

被引：9

作者：

DAVIS, R ^{[1
]}

WELLS, CHJ ^{[1
]}

TAYLOR, AR ^{[1
]}

机构：

[1] SERVIER LABS LTD,GREENFORD UB6 7PW,MIDDLESEX,ENGLAND

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 08期

关键词：

Diuretics—indapamide; photolytic and thermal decomposition; products identified; Indapamide—photolytic decomposition; thermal decomposition; decomposition products identified; Photolysis—indapamide; Thermolysis—indapamide;

D O I：

10.1002/jps.2600680840

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Photolytic decomposition of indapamide (I) in nitrogenflushed methanol yields 3‐sulfamoyl‐4‐chlorobenzamide (II), 2‐methylindoline (III), semicarbazide (IV), and 1‐(N‐formamido)‐2‐methylindoline (V); in oxygen‐flushed methanol, II—V, 1‐aminocarboxymethyl‐2‐methylindoline (VI), 3‐sulfamoyl‐4‐chlorobenzoic acid (VII), methyl‐3‐sulfamoyl‐4‐chlorobenzoate (VIII), and 2‐(N‐acetamido)‐benzoic acid (IX) are formed. A comparison is made with thermal decomposition of I. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1063 / 1064

页数：2