DISTRIBUTION OF PLATINUM CHEMOTHERAPEUTIC COMPLEXES IN NORMAL-TISSUES AND IN TUMORS

被引：8

作者：

DOUPLE, EB

HOWDEN, FM

HOESCHELE, JD

机构：

[1] DARTMOUTH COLL,HITCHCOCK MED CTR,DEPT RADIAT THERAPY,HANOVER,NH 03755

[2] OAK RIDGE NATL LAB,DIV HLTH & SAFETY RES,OAK RIDGE,TN 37830

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1979年 / 5卷 / 08期

关键词：

2-diaminocyclohexaneplatinum(II); !sup]195m[!/sup]Pt-labeled compounds; Atomic absorption spectrophotometry; Cis-dichloroammineplatinum(II); Malonato(-)-R; Mouse mammary adenocarcinoma; Platinum coordination complexes; R-1; Rat brain tumor;

D O I：

10.1016/0360-3016(79)90676-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pharmacokinetic studies in animals and in man have reported poor penetration of the parent platinum complex, cis-dichloroammineplatinum (cis-DDP), into the brain. In this study, levels of a 195mPt-labeled analog, malonato-diaminocyclohexaneplatinum(II) (PHM), were measured in tissues of normal and brain tumor-bearing rats between 1 and 30 hr after injection. Higher concentrations of platinum were recorded in tissues of tumor-bearing rats compared to tissues of normal animals and in intracerebral brain tumors compared to normal brain. A peak of a secondary maximum of uptake was observed at 24 hr. Results predict that it should be possible to obtain levels of platinum in the brain tumors on the order of levels that produced enhanced radiation effects in previous studies using cultured mammalian cells. © 1979.

引用

页码：1387 / 1391

页数：5

共 12 条

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