FORMATION OF ADDUCTS OF PARTHENIN AND RELATED SESQUITERPENE LACTONES WITH CYSTEINE AND GLUTATHIONE

被引：70

作者：

PICMAN, AK ^{[1
]}

RODRIGUEZ, E ^{[1
]}

TOWERS, GHN ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,DEPT ECOL & EVOLUT BIOL,IRVINE,CA 92664

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1979年 / 28卷 / 01期

关键词：

D O I：

10.1016/0009-2797(79)90116-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parthenin, the major sesquiterpene lactone of Parthenium hysterophorus, a weed responsible for dermatitis in man is primarily restricted to leaf and stem trichomes. Parthenin forms a monoadduct with L-cysteine through the α-methylene group of the γ-lactone and a biadduct with the endocyclic double bond on the cyclopentenone ring. Studies with other sesquiterpene lactones support the view that the types of adducts formed are correlated with the biological activity of the sesquiterpene lactones. © 1979.

引用

页码：83 / 89

页数：7

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