ANTI-CLOTTING PROPERTIES OF FRAGMENTS-D FROM HUMAN-FIBRINOGEN AND FIBRIN

被引：56

作者：

HAVERKATE, F

TIMAN, G

NIEUWENHUIZEN, W

机构：

[1] Gaubius Institute, Health Research Organization, TNO, Leiden

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1979年 / 9卷 / 04期

关键词：

anti‐clotting; Ca[!sup]2+[!/sup] ions; Fibrin(ogen) fragment D;

D O I：

10.1111/j.1365-2362.1979.tb00881.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abstract. It appeared from our previous studies that Ca2+ concentrations comparable to those occurring in blood protect the C‐terminal part of the γ‐chain remnants of fibrin(ogen) fragments D against further plasmin attack. This study shows that purified fibrin(ogen) fragments D formed in the presence of Ca2+ ions have anticlotting activity in vitro, whereas shortening of the γ‐chain remnants leads to loss of such activity. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：253 / 255

页数：3

共 17 条

[1] PATHOGENESIS OF COAGULATION DEFECT DEVELOPING DURING PATHOLOGICAL PLASMA PROTEOLYTIC (FIBRINOLYTIC) STATES .2. SIGNIFICANCE, MECHANISM AND CONSEQUENCES OF DEFECTIVE FIBRIN POLYMERIZATION
ALKJAERSIG, N
SHERRY, S
FLETCHER, AP
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1962, 41 (04) : 917 - &
[2] Castellino F J, 1976, Methods Enzymol, V45, P273
[3] Chibber B A, 1974, Methods Enzymol, V34, P424
[4] FRAGMENTS-D - CORRELATION BETWEEN STRUCTURE AND BIOLOGICAL-ACTIVITY
DRAYATTALI, L
LARRIEU, MJ
[J]. THROMBOSIS RESEARCH, 1977, 10 (04) : 575 - 586
[5] PROTECTIVE EFFECT OF CALCIUM IN PLASMIN DEGRADATION OF FIBRINOGEN AND FIBRIN FRAGMENTS-D
HAVERKATE, F
TIMAN, G
[J]. THROMBOSIS RESEARCH, 1977, 10 (06) : 803 - 812
[6] HAVERKATE F, 1976, PROGR CHEM FIBRINOLY, V2, P73
[7] MANWARING D, 1978, SURGERY, V84, P45
[8] Marder V J, 1974, Prog Hemost Thromb, V2, P141
[9] MARDER VJ, 1969, J BIOL CHEM, V244, P2120
[10] CALCIUM-BINDING PROPERTIES OF HUMAN FIBRIN(OGEN) AND DEGRADATION PRODUCTS
NIEUWENHUIZEN, W
VERMOND, A
NOOIJEN, WJ
HAVERKATE, F
[J]. FEBS LETTERS, 1979, 98 (02) : 257 - 259

← 1 2 →