POLYMERIZATION OF LIPOSOMES EVALUATED FROM MOLECULAR-WEIGHT DISTRIBUTION OF DIENE-TYPE PHOSPHOLIPID POLYMERS

被引：8

作者：

TAKEOKA, S ^{[1
]}

KIMURA, N ^{[1
]}

OHNO, H ^{[1
]}

TSUCHIDA, E ^{[1
]}

机构：

[1] WASEDA UNIV,DEPT POLYMER CHEM,TOKYO 169,JAPAN

来源：

POLYMER JOURNAL | 1990年 / 22卷 / 10期

关键词：

Diene containing phospholipid; Liposomes; Molecular weight distribution; Uv-irradiation;

D O I：

10.1295/polymj.22.867

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

1, 2-Bis(2, 4-octadecadienoyl)-sn-glycero-3-phosphorylcholine (DODPC) or 1-palmitoyl-2-(2, 4-octadecadienoyl)-sn-glycero-3-phosphorylcholine (POPC) was dispersed in water by sonication to form liposomes. DODPC liposomes were polymerized by UV-irradiation or with radical initiator such as azobis(2-amidinopropane)dihydrochloride (AAPD) at 60°C and methanolyzed to obtain THF-soluble polymers. The molecular weight distribution obtained from a gel permeation chromatography reveals that the UV-irradiation provides low-molecular-weight products and a small amount of polymers, while free radical polymerization gives polymers having relatively high-molecular-weight. The molecular weight of the phospholipid polymers is also influenced by the assembling state. The constrained lipid packing of small unilamellar POPC liposomes provides relatively low-molecular-weight polymers in comparison with those of larger liposomes. In addition, POPC liposomes polymerized at the temperature above the gel-to-liquid crystalline phase transition temperature (Tc) show the higher molecular weight of polymers than those polymerized below the Tc. © 1990 The Society of Polymer Science, Japan.

引用

页码：867 / 874

页数：8

共 24 条

[1]

BADER H, 1985, ADV POLYM SCI, V64, P1

[2] DEGREE OF POLYMERIZATION OF A VESICLE MEMBRANE [J].

BOLIKAL, D ;

REGEN, SL .

MACROMOLECULES, 1984, 17 (06) :1287-1289

[3]

DORN K, 1983, MAKROMOL CHEM-RAPID, V4, P513

[4]

Fendler J. H., 1982, MEMBRANE MIMETIC CHE

[5]

FENDLER JH, 1985, ISRAEL J CHEM, V25, P3

[6]

Gregoriadis G., 1984, LIPOSOME TECHNOLOGY

[7] POLYMERIC ANTI-TUMOR AGENTS ON A MOLECULAR AND ON A CELLULAR-LEVEL [J].

GROS, L ;

RINGSDORF, H ;

SCHUPP, H .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1981, 20 (04) :305-325

[8]

LAUSCEWSKY A, 1988, MACROMOLECULES, V21, P1936

[9] EFFECT OF SURFACE CURVATURE ON STABILITY, THERMODYNAMIC BEHAVIOR, AND OSMOTIC ACTIVITY OF DIPALMITOYLPHOSPHATIDYLCHOLINE SINGLE LAMELLAR VESICLES [J].

LICHTENBERG, D ;

FREIRE, E ;

SCHMIDT, CF ;

BARENHOLZ, Y ;

FELGNER, PL ;

THOMPSON, TE .

BIOCHEMISTRY, 1981, 20 (12) :3462-3467

[10]

MATSUSHITA Y, 1987, MAKROMOL CHEM-RAPID, V8, P1

← 1 2 3 →