EFFECT OF SERUM-LIPOPROTEINS OF BILE OBSTRUCTED RATS ON 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE-ACTIVITY IN PERFUSED RAT-LIVER

被引：5

作者：

BARAK, AJ ^{[1
]}

SORRELL, MF ^{[1
]}

TUMA, DJ ^{[1
]}

机构：

[1] UNIV NEBRASKA,MED CTR,DEPT MED,OMAHA,NE 68105

来源：

LIPIDS | 1979年 / 14卷 / 11期

关键词：

D O I：

10.1007/BF02533500

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Total lipoproteins as well as fractionated VLDL+LDL and HDL from fasted control rats and bileligated rats were tested in liver perfusion for their effect on 3-hydroxy-3-methylglutaryl CoA reductase to increase 3-hydroxy-3-methylglutaryl CoA reductase activity than that of the control total lipoproteins. When the fractionated lipoproteins were tested from fasted control rats, it was found that the major stimulating activity was in the HDL fraction with minor activity in the VLDL+LDL fraction. When these plasma components isolated from fasted bile-ligated rats were tested, it was found that the major activity had shifted to the VLDL+LDL fraction with the HDL having only a minor stimulatory role. The possible mechanism of action of the abnormal lipoproteins associated with bile obstruction in regulating 3-hydroxy-3-methylglutaryl CoA reductase activity is discussed. © 1979 American Oil Chemists' Society.

引用

页码：883 / 887

页数：5

共 26 条

[1] RATE CONSTANTS FOR UPTAKE OF CHOLESTEROL FROM VARIOUS INTESTINAL AND SERUM LIPOPROTEIN FRACTIONS BY LIVER OF RAT INVIVO [J].