TRANSCRIPTION FACTOR ACTIVATION AND FUNCTIONAL STIMULATION OF HUMAN MONOCYTES

被引：12

作者：

KAMINSKA, B ^{[1
]}

KACZMAREK, L ^{[1
]}

MALAGUARNERA, L ^{[1
]}

ARCIDIACONO, A ^{[1
]}

MESSINA, L ^{[1
]}

SPAMPINATO, G ^{[1
]}

MESSINA, A ^{[1
]}

机构：

[1] UNIV CATANIA,INST GEN PATHOL,I-95124 CATANIA,ITALY

来源：

CELL BIOLOGY INTERNATIONAL REPORTS | 1992年 / 16卷 / 01期

关键词：

D O I：

10.1016/S0309-1651(06)80154-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Activation of expression of genes encoding transcription factors: c-fos and c-jun and formation of AP1 transcriptional complex in human monocytes was investigated. It was found that lipopolysaccharide induced strongly both c-fos and c-jun expression as well as AP1 formation. Interferon γ activated strongly c-fos and weakly c-jun and AP1. Tumor necrosis factor induced slightly c-fos and had almost no effect on c-jun and AP1. The data suggest that differences in functional responses elicited in monocytes by all three factors may be dependent on different routes on nuclear signalling employed by the factors. © 1992 Academic Press Ltd.

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页码：37 / 45

页数：9

相关论文

共 18 条

[1] OXYGEN-DEPENDENT MICROBIAL KILLING BY PHAGOCYTES .1. [J].

BABIOR, BM .

NEW ENGLAND JOURNAL OF MEDICINE, 1978, 298 (12) :659-668

[2] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT [J].

BABIOR, BM ;

KIPNES, RS ;

CURNUTTE, JT .

JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (03) :741-744

[3] GROWTH-FACTORS AND MEMBRANE DEPOLARIZATION ACTIVATE DISTINCT PROGRAMS OF EARLY RESPONSE GENE-EXPRESSION - DISSOCIATION OF FOS AND JUN INDUCTION [J].

BARTEL, DP ;

SHENG, M ;

LAU, LF ;

GREENBERG, ME .

GENES & DEVELOPMENT, 1989, 3 (03) :304-313

[4] THE C-FOS PROTEIN INTERACTS WITH C-JUN/AP-1 TO STIMULATE TRANSCRIPTION OF AP-1 RESPONSIVE GENES [J].

CHIU, R ;

BOYLE, WJ ;

MEEK, J ;

SMEAL, T ;

HUNTER, T ;

KARIN, M .

CELL, 1988, 54 (04) :541-552

[5]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[6] GAMMA-INTERFERON ENHANCES MACROPHAGE TRANSCRIPTION OF THE TUMOR-NECROSIS-FACTOR CACHECTIN, INTERLEUKIN-1, AND UROKINASE GENES, WHICH ARE CONTROLLED BY SHORT-LIVED REPRESSORS [J].

COLLART, MA ;

BELIN, D ;

VASSALLI, JD ;

DEKOSSODO, S ;

VASSALLI, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (06) :2113-2118

[7] FOS AND JUN - THE AP-1 CONNECTION [J].

CURRAN, T ;

FRANZA, BR .

CELL, 1988, 55 (03) :395-397

[8] HOMOLOGOUS AND HETEROLOGOUS DESENSITIZATION OF PROTOONCOGENE CFOS EXPRESSION IN MURINE PERITONEAL-MACROPHAGES [J].

INTRONA, M ;

BAST, RC ;

JOHNSTON, PA ;

ADAMS, DO ;

HAMILTON, TA .

JOURNAL OF CELLULAR PHYSIOLOGY, 1987, 131 (01) :36-42

[9] ROLE OF SUPEROXIDE ANION GENERATION IN PHAGOCYTIC BACTERICIDAL ACTIVITY - STUDIES WITH NORMAL AND CHRONIC GRANULOMATOUS DISEASE LEUKOCYTES [J].

JOHNSTON, RB ;

KEELE, BB ;

MISRA, HP ;

LEHMEYER, JE ;

WEBB, LS ;

BAEHNER, RL ;

RAJAGOPALAN, KV .

JOURNAL OF CLINICAL INVESTIGATION, 1975, 55 (06) :1357-1372

[10]

JOHNSTON RB, 1978, J EXP MED, V148, P115