INACTIVATION OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS (SRS-A) BY LIPOXIDASE

被引：37

作者：

SIROIS, P ^{[1
]}

机构：

[1] HOSP SICK CHILDREN,DEPT IMMUNOL,TORONTO M5G 1X8,ONTARIO,CANADA

来源：

PROSTAGLANDINS | 1979年 / 17卷 / 03期

关键词：

D O I：

10.1016/S0090-6980(79)80007-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipoxidase (E.C.1.13.1.13) inactivates rat SRS-A. The inactivation is time, temperature, and concentration-dependant. Linoleic acid and eicosatetraynoic acid inhibit the enzymatic deactivation of the mediator. It is concluded that SRS-A is a genuine substrate for lipoxidase and contains a cis, cis-1, 4-pentadiene structure. It is suggested that lipoxidase could play a major role in tissue removal of the mediator during hypersensitivity reactions. © 1979.

引用

页码：395 / 404

页数：10

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