A DIECKMANN/RING EXPANSION APPROACH TO TETRAHYDROPYRIDO[1,2-A]INDOLES AND TETRAHYDROAZEPINO[1,2-A]INDOLES

被引:29
作者
BIT, RA [1 ]
DAVIS, PD [1 ]
HILL, CH [1 ]
KEECH, E [1 ]
VESEY, DR [1 ]
机构
[1] ROCHE PROD LTD,POB 8,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND
关键词
D O I
10.1016/S0040-4020(01)86471-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A general Dieckmann/ring expansion approach to fused [1,2-a]indole systems is reported. This approach has allowed the synthesis of a large variety of substituted systems required for the preparation of a series of potent and selective inhibitors of Protein Kinase C.
引用
收藏
页码:4645 / 4664
页数:20
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