SLOW-RELEASE TECHNIQUE FOR INDUCING PROLONGED PARALYSIS BY TETRODOTOXIN

被引:26
作者
MILLS, RG
BRAY, JJ
机构
[1] Department of Physiology, University of Otago Medical School, Dunedin
来源
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1979年 / 383卷 / 01期
关键词
Nerve block; Paralysis; Slow-release technique; Tetrodotoxin;
D O I
10.1007/BF00584476
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
A technique is described for the slow-release of tetrodotoxin in peripheral nerves using a constriction capillary. The capillary, which was implanted under the epineurium of the sciatic nerve, released tetrodotoxin from a 25 μm pore. Nerve block was complete after approximately 20 min and lasted 6-9 days. Replacement of the capillary enabled paralysis of the rat hindlimb to be maintained for periods of 21 days and longer. Studies with radioactively labelled compounds demonstrated that the efflux rate from the capillary was dependent on the size of the pore and the relative molecular mass of the compound. © 1979 Springer-Verlag.
引用
收藏
页码:67 / 70
页数:4
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