INCREASED CIRCULATING INTERLEUKIN-1 AND INTERLEUKIN-6 AFTER INTRACEREBROVENTRICULAR INJECTION OF LIPOPOLYSACCHARIDE

被引:51
作者
GOTTSCHALL, PE
KOMAKI, G
ARIMURA, A
机构
[1] TULANE UNIV,HEBERT CTR,US JAPAN BIOMED RES LABS,3705 MAIN ST,BELLE CHASSE,LA 70037
[2] TULANE UNIV,SCH MED,DEPT MED,NEW ORLEANS,LA 70112
[3] TULANE UNIV,SCH MED,DEPT ANAT,NEW ORLEANS,LA 70112
[4] TULANE UNIV,SCH MED,DEPT PHYSIOL,NEW ORLEANS,LA 70112
关键词
INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDE; NEUROIMMUNOMODULATION;
D O I
10.1159/000126328
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recently, it was demonstrated that intracerebroventricular (icv) injection of interleukin-1 (IL-1) stimulated circulating interleukin-6(IL-6) to a greater degree than intravenous (iv) injection of IL-1. The goal of this study was to compare the efficacy of lipopolysaccharide (LPS), injected both icv and iv, on circulating concentrations of IL-1 and IL-6. Both iv and icv injection of LPS stimulated plasma levels of IL-1 to a similar degree. However, iv injection of LPS was significantly more efficacious than icv injection of LPS in elevating circulating IL-6. These results demonstrate that like iv injection of LPS, icv injection of LPS stimulates plasma levels of IL-1 and IL-6. Increases in circulating cytokines during infectious diseases which are limited to the central nervous system may serve to activate peripheral functions of an acute phase response.
引用
收藏
页码:935 / 938
页数:4
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