PRESYNAPTIC INHIBITORY EFFECT OF TNF-ALPHA ON THE RELEASE OF NORADRENALINE IN ISOLATED MEDIAN-EMINENCE

被引：62

作者：

ELENKOV, IJ

KOVACS, K

DUDA, E

STARK, E

VIZI, ES ^{[1
]}

机构：

[1] HUNGARIAN ACAD SCI,INST EXPTL MED,POB 67,H-1450 BUDAPEST,HUNGARY

[2] BIOL RES CTR,INST BIOCHEM,H-6701 SZEGED,HUNGARY

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 41卷 / 01期

关键词：

TUMOR NECROSIS FACTOR-ALPHA; MEDIAN EMINENCE; NORADRENALINE RELEASE; PRESYNAPTIC MODULATION; NEUROIMMUNE COMMUNICATION;

D O I：

10.1016/0165-5728(92)90203-W

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of tumor necrosis factor-alpha (TNF-alpha) on the stimulation-evoked release of noradrenaline (NA) from isolated rat median eminence (ME) was investigated, using a low-volume perfusion system. Median eminence, loaded with [H-3]noradrenaline, was superfused with Krebs solution and stimulated electrically (2 Hz, 120 shocks). The effect of TNF-alpha was studied on the S2/S1 ratio. It was found that stimulation-evoked release of NA from noradrenergic axon terminals in the isolated rat ME was inhibited by TNF-alpha and this effect was concentration-dependent. In contrast, TNF-alpha had no effect on the release of [H-3]NA from the spleen. Since NA released in the ME might be involved in the modulation of corticotropin-releasing factor (CRF) production, it is suggested that TNF-alpha, through presynaptic modulation of NA release from noradrenergic nerve terminals in the ME, might regulate CRF and other neurohormone release in this hypothalamic structure.

引用

页码：117 / 120

页数：4

共 24 条

[1] CORTICOTROPIN-RELEASING FACTOR PRODUCING NEURONS IN THE RAT ACTIVATED BY INTERLEUKIN-1
BERKENBOSCH, F
VANOERS, J
DELREY, A
TILDERS, F
BESEDOVSKY, H
[J]. SCIENCE, 1987, 238 (4826) : 524 - 526
[2] INTERACTIONS BETWEEN TUMOR NECROSIS FACTOR-ALPHA, HYPOTHALAMIC CORTICOTROPIN-RELEASING HORMONE, AND ADRENOCORTICOTROPIN SECRETION IN THE RAT
BERNARDINI, R
KAMILARIS, TC
CALOGERO, AE
JOHNSON, EO
GOMEZ, MT
GOLD, PW
CHROUSOS, GP
[J]. ENDOCRINOLOGY, 1990, 126 (06) : 2876 - 2881
[3] RELEASE OF MULTIPLE HORMONES BY A DIRECT ACTION OF INTERLEUKIN-1 ON PITUITARY-CELLS
BERNTON, EW
BEACH, JE
HOLADAY, JW
SMALLRIDGE, RC
FEIN, HG
[J]. SCIENCE, 1987, 238 (4826) : 519 - 521
[4] IMMUNOREGULATORY FEEDBACK BETWEEN INTERLEUKIN-1 AND GLUCOCORTICOID HORMONES
BESEDOVSKY, H
DELREY, A
SORKIN, E
DINARELLO, CA
[J]. SCIENCE, 1986, 233 (4764) : 652 - 654
[5] THE IMMUNE-RESPONSE EVOKES CHANGES IN BRAIN NORADRENERGIC NEURONS
BESEDOVSKY, H
DELREY, A
SORKIN, E
DAPRADA, M
BURRI, R
HONEGGER, C
[J]. SCIENCE, 1983, 221 (4610) : 564 - 566
[6] WHAT DO THE IMMUNE-SYSTEM AND THE BRAIN KNOW ABOUT EACH OTHER
BESEDOVSKY, HO
DELREY, AE
SORKIN, E
[J]. IMMUNOLOGY TODAY, 1983, 4 (12): : 342 - 346
[7] A MOLECULAR-BASIS FOR BIDIRECTIONAL COMMUNICATION BETWEEN THE IMMUNE AND NEURO-ENDOCRINE SYSTEMS
BLALOCK, JE
[J]. PHYSIOLOGICAL REVIEWS, 1989, 69 (01) : 1 - 32
[8] ACUTE CHANGES IN NOREPINEPHRINE CONTENT IN MEDIAN-EMINENCE INDUCED BY ORCHIDECTOMY OR TESTOSTERONE REPLACEMENT
CHIOCCHIO, SR
NEGROVILAR, A
TRAMEZZANI, JH
[J]. ENDOCRINOLOGY, 1976, 99 (02) : 629 - 635
[9] MODULATION OF CORTICOTROPHIN-RELEASING FACTOR RELEASE FROM HYPOTHALAMIC SYNAPTOSOMES
EDWARDSON, JA
BENNETT, GW
[J]. NATURE, 1974, 251 (5474) : 425 - 427
[10] PRESYNAPTIC MODULATION OF RELEASE OF NORADRENALINE FROM THE SYMPATHETIC-NERVE TERMINALS IN THE RAT SPLEEN
ELENKOV, IJ
VIZI, ES
[J]. NEUROPHARMACOLOGY, 1991, 30 (12A) : 1319 - 1324

← 1 2 3 →