ANTI-MICHAEL ADDITION OF CYANOCUPRATE TBUCU(CN)LI TO ACCEPTOR-SUBSTITUTED ENYNES

被引：14

作者：

GEROLD, A ^{[1
]}

KRAUSE, N ^{[1
]}

机构：

[1] TH DARMSTADT,INST ORGAN CHEM,PETERSENSTR 22,D-64287 DARMSTADT,GERMANY

来源：

CHEMISCHE BERICHTE | 1994年 / 127卷 / 08期

关键词：

CUPRATES; ORGANOMETALLIC; ENYNES; ACCEPTOR-SUBSTITUTED; ADDITION; REGIOSELECTIVITY OF; ANTI-MICHAEL ADDITION; PROTONATION;

D O I：

10.1002/cber.19941270833

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acceptor-substituted enynes 1 react with lithium tert-butylcyanocuprate [tBuCu(CN)Li] in THF to afford anti-Michael adducts 3. The formation of the isomeric side products 4 can be suppressed by regioselective protonation of the organometallic intermediates with ethanol at -80-degrees-C. Evidence for radical intermediates or electron-transfer steps in these reactions could not be obtained.

引用

页码：1547 / 1549

页数：3

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