MYELIN MEMBRANE BIOGENESIS BY OLIGODENDROCYTES - DEVELOPMENTAL REGULATION OF LOW-MOLECULAR-WEIGHT GTP-BINDING PROTEINS

被引：50

作者：

HUBER, LA

MADISON, DL

SIMONS, K

PFEIFFER, SE

机构：

[1] EUROPEAN MOLEC BIOL LAB,DEPT CELL BIOL,W-6900 HEIDELBERG,GERMANY

[2] UNIV CONNECTICUT,SCH MED,DEPT MICROBIOL,FARMINGTON,CT 06030

来源：

FEBS LETTERS | 1994年 / 347卷 / 2-3期

关键词：

GTP-BINDING PROTEIN; RAB PROTEIN; OLIGODENDROCYTE; MYELIN BIOGENESIS; VESICULAR TRAFFICKING;

D O I：

10.1016/0014-5793(94)00562-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oligodendrocytes synthesize dramatic amounts of myelin membrane. We hypothesized that this requires unique aspects of vesicular trafficking. Specific stages of the oligodendrocyte lineage were assayed for low molecular weight GTP-binding proteins implicated in the regulation of vesicular transport pathway (two dimensional gel electrophoresis, [alpha-P-32]GTP overlay). Consistent with the hypothesis, as oligodendrocytes differentiate from early progenitors to mature myelin-producing cells, greater than or equal to 12 small GTP-binding proteins become up-regulated. Myelin membrane also has a complex pattern of GTP-binding proteins. Several of these proteins may be specific to oligodendrocytes, suggesting that oligodendrocytes may utilize cell-type specific GTP-binding proteins for biogenesis and maintenance of the myelin membrane.

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页码：273 / 278

页数：6

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