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REGULATION OF THE IMMUNE-RESPONSE BY POLYAMINES
被引:12
作者
:
DWYER, DS
论文数:
0
引用数:
0
h-index:
0
机构:
Neurosciences Program, University of Alabama in Birmingham, Birmingham
DWYER, DS
机构
:
[1]
Neurosciences Program, University of Alabama in Birmingham, Birmingham
来源
:
MEDICAL HYPOTHESES
|
1979年
/ 5卷
/ 11期
关键词
:
immunoregulation;
membrane stabilization;
polyamines;
protein crosslinking;
D O I
:
10.1016/0306-9877(79)90001-X
中图分类号
:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号
:
1001 ;
摘要
:
Regulation of the immune system is accomplished, in part, by numerous soluble factors and small molecules. One such class of regulatory substance may be the polyamines which are present in a variety of tissues. Stimulation of the immune response often occurs by crosslinking of lymphocyte surface proteins, followed by the production of some transmembrane signal. The activation pathway may be interrupted if certain necessary steps are blocked. It is proposed that polyamines exert regulatory influences by modulating crosslink formation; a step catalyzed by the enzyme transglutaminase. A model is outlined which describes the events initiating lymphocyte activation and the role of polyamines in this process. Certain drugs which might mimic the actions of polyamines are also discussed. During evolution of the control of growth processes in cells, relatively simple molecules (the polyamines) may have assumed a pivotal role in initiating and terminating the proliferative response. This idea has been applied to regulation of the immune system. © 1979.
引用
收藏
页码:1169 / 1181
页数:13
相关论文
共 56 条
[1]
IDENTIFICATION OF A THYMIC INHIBITOR (CHALONE) OF LYMPHOCYTE-TRANSFORMATION AS A SPERMINE COMPLEX
ALLEN, JC
论文数:
0
引用数:
0
h-index:
0
机构:
KELSTERTON COLL,N E WALES INST,BIOCHEM RES UNIT,CLWYD,WALES
ALLEN, JC
SMITH, CJ
论文数:
0
引用数:
0
h-index:
0
机构:
KELSTERTON COLL,N E WALES INST,BIOCHEM RES UNIT,CLWYD,WALES
SMITH, CJ
CURRY, MC
论文数:
0
引用数:
0
h-index:
0
机构:
KELSTERTON COLL,N E WALES INST,BIOCHEM RES UNIT,CLWYD,WALES
CURRY, MC
GAUGAS, JM
论文数:
0
引用数:
0
h-index:
0
机构:
KELSTERTON COLL,N E WALES INST,BIOCHEM RES UNIT,CLWYD,WALES
GAUGAS, JM
[J].
NATURE,
1977,
267
(5612)
: 623
-
625
[2]
CYCLIC AMP-MEDIATED INDUCTION OF ORNITHINE DECARBOXYLASE OF GLIOMA AND NEUROBLASTOMA-CELLS
BACHRACH, U
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI, LAB BIOCHEM GENET, BETHESDA, MD 20014 USA
NHLI, LAB BIOCHEM GENET, BETHESDA, MD 20014 USA
BACHRACH, U
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1975,
72
(08)
: 3087
-
3091
[3]
EFFECT OF POLYAMINES ON PROLIFERATIVE RESPONSE OF T-CELLS STIMULATED WITH ANTIGEN
BALLET, JJ
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,MED SCH,DEPT PEDIAT,BOSTON,MA
BALLET, JJ
PREISIG, E
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,MED SCH,DEPT PEDIAT,BOSTON,MA
PREISIG, E
MERLER, E
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,MED SCH,DEPT PEDIAT,BOSTON,MA
MERLER, E
[J].
EUROPEAN JOURNAL OF IMMUNOLOGY,
1975,
5
(12)
: 844
-
849
[4]
IN-VIVO STIMULATION OF RAT-LIVER ORNITHINE DECARBOXYLASE ACTIVITY BY DIBUTYRYL CYCLIC ADENOSINE 3',5'-MONOPHOSPHATE, THEOPHYLLINE AND DEXAMETHASONE
BECK, WT
论文数:
0
引用数:
0
h-index:
0
BECK, WT
BELLANTONE, RA
论文数:
0
引用数:
0
h-index:
0
BELLANTONE, RA
CANELLAKIS, ES
论文数:
0
引用数:
0
h-index:
0
CANELLAKIS, ES
[J].
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1972,
48
(06)
: 1649
-
+
[5]
DISTINCT EFFECTS OF DIAMINES, POLYAMINES, AND MAGNESIUM IONS ON STABILITY OF LAMBDA-PHAGE HEADS
BODE, VC
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MARYLAND,MED SCH,DEPT BIOCHEM,BALTIMORE,MD 21201
BODE, VC
HARRISON, DP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MARYLAND,MED SCH,DEPT BIOCHEM,BALTIMORE,MD 21201
HARRISON, DP
[J].
BIOCHEMISTRY,
1973,
12
(17)
: 3193
-
3196
[6]
SYNTHETIC POLYAMINES ADDED TO CULTURES CONTAINING BOVINE SERA REVERSIBLY INHIBIT INVITRO PARAMETERS OF IMMUNITY
BYRD, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92112
SALK INST BIOL STUDIES,SAN DIEGO,CA 92112
BYRD, WJ
JACOBS, DM
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92112
SALK INST BIOL STUDIES,SAN DIEGO,CA 92112
JACOBS, DM
AMOSS, MS
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92112
SALK INST BIOL STUDIES,SAN DIEGO,CA 92112
AMOSS, MS
[J].
NATURE,
1977,
267
(5612)
: 621
-
623
[7]
BYRD WJ, 1978, ADV POLYAMINE RES, P71
[8]
CANELLAKIS ES, 1978, ADV POLYAMINE RES, V1, P17
[9]
I125 LABELED HUMAN EPIDERMAL GROWTH-FACTOR - BINDING, INTERNALIZATION, AND DEGRADATION IN HUMAN FIBROBLASTS
CARPENTER, G
论文数:
0
引用数:
0
h-index:
0
机构:
VANDERBILT UNIV, DEPT BIOCHEM, NASHVILLE, TN 37232 USA
VANDERBILT UNIV, DEPT BIOCHEM, NASHVILLE, TN 37232 USA
CARPENTER, G
COHEN, S
论文数:
0
引用数:
0
h-index:
0
机构:
VANDERBILT UNIV, DEPT BIOCHEM, NASHVILLE, TN 37232 USA
VANDERBILT UNIV, DEPT BIOCHEM, NASHVILLE, TN 37232 USA
COHEN, S
[J].
JOURNAL OF CELL BIOLOGY,
1976,
71
(01)
: 159
-
171
[10]
COMPARATIVE STUDIES ON TISSUE TRANSGLUTAMINASE AND FACTOR XIII
CHUNG, SI
论文数:
0
引用数:
0
h-index:
0
机构:
NIDR,LAB BIOCHEM,BETHESDA,MD 20014
NIDR,LAB BIOCHEM,BETHESDA,MD 20014
CHUNG, SI
[J].
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,
1972,
202
(DEC8)
: 240
-
255
←
1
2
3
4
5
6
→
共 56 条
[1]
IDENTIFICATION OF A THYMIC INHIBITOR (CHALONE) OF LYMPHOCYTE-TRANSFORMATION AS A SPERMINE COMPLEX
ALLEN, JC
论文数:
0
引用数:
0
h-index:
0
机构:
KELSTERTON COLL,N E WALES INST,BIOCHEM RES UNIT,CLWYD,WALES
ALLEN, JC
SMITH, CJ
论文数:
0
引用数:
0
h-index:
0
机构:
KELSTERTON COLL,N E WALES INST,BIOCHEM RES UNIT,CLWYD,WALES
SMITH, CJ
CURRY, MC
论文数:
0
引用数:
0
h-index:
0
机构:
KELSTERTON COLL,N E WALES INST,BIOCHEM RES UNIT,CLWYD,WALES
CURRY, MC
GAUGAS, JM
论文数:
0
引用数:
0
h-index:
0
机构:
KELSTERTON COLL,N E WALES INST,BIOCHEM RES UNIT,CLWYD,WALES
GAUGAS, JM
[J].
NATURE,
1977,
267
(5612)
: 623
-
625
[2]
CYCLIC AMP-MEDIATED INDUCTION OF ORNITHINE DECARBOXYLASE OF GLIOMA AND NEUROBLASTOMA-CELLS
BACHRACH, U
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI, LAB BIOCHEM GENET, BETHESDA, MD 20014 USA
NHLI, LAB BIOCHEM GENET, BETHESDA, MD 20014 USA
BACHRACH, U
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1975,
72
(08)
: 3087
-
3091
[3]
EFFECT OF POLYAMINES ON PROLIFERATIVE RESPONSE OF T-CELLS STIMULATED WITH ANTIGEN
BALLET, JJ
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,MED SCH,DEPT PEDIAT,BOSTON,MA
BALLET, JJ
PREISIG, E
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,MED SCH,DEPT PEDIAT,BOSTON,MA
PREISIG, E
MERLER, E
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,MED SCH,DEPT PEDIAT,BOSTON,MA
MERLER, E
[J].
EUROPEAN JOURNAL OF IMMUNOLOGY,
1975,
5
(12)
: 844
-
849
[4]
IN-VIVO STIMULATION OF RAT-LIVER ORNITHINE DECARBOXYLASE ACTIVITY BY DIBUTYRYL CYCLIC ADENOSINE 3',5'-MONOPHOSPHATE, THEOPHYLLINE AND DEXAMETHASONE
BECK, WT
论文数:
0
引用数:
0
h-index:
0
BECK, WT
BELLANTONE, RA
论文数:
0
引用数:
0
h-index:
0
BELLANTONE, RA
CANELLAKIS, ES
论文数:
0
引用数:
0
h-index:
0
CANELLAKIS, ES
[J].
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1972,
48
(06)
: 1649
-
+
[5]
DISTINCT EFFECTS OF DIAMINES, POLYAMINES, AND MAGNESIUM IONS ON STABILITY OF LAMBDA-PHAGE HEADS
BODE, VC
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MARYLAND,MED SCH,DEPT BIOCHEM,BALTIMORE,MD 21201
BODE, VC
HARRISON, DP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MARYLAND,MED SCH,DEPT BIOCHEM,BALTIMORE,MD 21201
HARRISON, DP
[J].
BIOCHEMISTRY,
1973,
12
(17)
: 3193
-
3196
[6]
SYNTHETIC POLYAMINES ADDED TO CULTURES CONTAINING BOVINE SERA REVERSIBLY INHIBIT INVITRO PARAMETERS OF IMMUNITY
BYRD, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92112
SALK INST BIOL STUDIES,SAN DIEGO,CA 92112
BYRD, WJ
JACOBS, DM
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92112
SALK INST BIOL STUDIES,SAN DIEGO,CA 92112
JACOBS, DM
AMOSS, MS
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92112
SALK INST BIOL STUDIES,SAN DIEGO,CA 92112
AMOSS, MS
[J].
NATURE,
1977,
267
(5612)
: 621
-
623
[7]
BYRD WJ, 1978, ADV POLYAMINE RES, P71
[8]
CANELLAKIS ES, 1978, ADV POLYAMINE RES, V1, P17
[9]
I125 LABELED HUMAN EPIDERMAL GROWTH-FACTOR - BINDING, INTERNALIZATION, AND DEGRADATION IN HUMAN FIBROBLASTS
CARPENTER, G
论文数:
0
引用数:
0
h-index:
0
机构:
VANDERBILT UNIV, DEPT BIOCHEM, NASHVILLE, TN 37232 USA
VANDERBILT UNIV, DEPT BIOCHEM, NASHVILLE, TN 37232 USA
CARPENTER, G
COHEN, S
论文数:
0
引用数:
0
h-index:
0
机构:
VANDERBILT UNIV, DEPT BIOCHEM, NASHVILLE, TN 37232 USA
VANDERBILT UNIV, DEPT BIOCHEM, NASHVILLE, TN 37232 USA
COHEN, S
[J].
JOURNAL OF CELL BIOLOGY,
1976,
71
(01)
: 159
-
171
[10]
COMPARATIVE STUDIES ON TISSUE TRANSGLUTAMINASE AND FACTOR XIII
CHUNG, SI
论文数:
0
引用数:
0
h-index:
0
机构:
NIDR,LAB BIOCHEM,BETHESDA,MD 20014
NIDR,LAB BIOCHEM,BETHESDA,MD 20014
CHUNG, SI
[J].
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,
1972,
202
(DEC8)
: 240
-
255
←
1
2
3
4
5
6
→