ADMINISTRATION OF ANTI-TNF ANTIBODY IMPROVES LEFT-VENTRICULAR FUNCTION IN SEPTIC SHOCK PATIENTS - RESULTS OF A PILOT-STUDY

被引:154
作者
VINCENT, JL [1 ]
BAKKER, J [1 ]
MARECAUX, G [1 ]
SCHANDENE, L [1 ]
KAHN, RJ [1 ]
DUPONT, E [1 ]
机构
[1] FREE UNIV BRUSSELS,ERASME UNIV HOSP,DEPT IMMUNOL,B-1070 BRUSSELS,BELGIUM
关键词
D O I
10.1378/chest.101.3.810
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
In this pilot study, murine monoclonal anti-TNF antibody (2 mg/kg) was administered to ten patients within 24 h of septic shock which persisted after initial resuscitation with intravenous fluids and adrenergic agents. This treatment resulted in a reduction in heart rate (from 122 +/- 10 to 113 +/- 10 beats per minute at 4 h, p < 0.01) associated with an increase in LVSWI (from 26.5 +/- 5.6 to 31.5 +/- 10.5 g.m2 at 2 h, p < 0.05), indicating in the absence of change in cardiac filling pressures, an improvement in ventricular function. Arterial oxygenation improved concurrently in six patients. These changes, however, appeared transient. The improvement in cardiac function following anti-TNF anti-body administration in patients is in keeping with recent experimental studies indicating the role of TNF in the myocardial depression characterizing septic shock.
引用
收藏
页码:810 / 815
页数:6
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