SYNTHESES OF POTENTIAL SPIN PROBES FOR BIOMEMBRANES - TEMPO AND PROXYL NITROXIDES OF LITHOCHOLIC ACID

被引：13

作者：

BANERJEE, S

TRIVEDI, GK

机构：

[1] Department of Chemistry Indian Institute of Technology Powai, Bombay

来源：

TETRAHEDRON | 1992年 / 48卷 / 45期

关键词：

D O I：

10.1016/S0040-4020(01)92284-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a steroidal spin label 10 containing a tempo nitroxide group in the side chain of lithocholic acid 1 is reported. This is the first report of a tempo nitroxide in d steroidal side chain. The methodology involved d Wittig condensation between the steroidal phosphonium ylide 7 and tempone 9. The synthesis Of d proxyl nitroxide 16 with the proxyl group in the side chain of 1 is also described. A mild oxidation of 16 to the corresponding 3-keto spin label 17 in high yield is also achieved.

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页码：9939 / 9950

页数：12

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