ISOLATION OF LESS-THAN-GLU-ASN-PHE-HIS-LEU-ARG-PRO-NH2 (ANTHO-RPAMIDE-II), A NOVEL, BIOLOGICALLY-ACTIVE NEUROPEPTIDE FROM SEA-ANEMONES

被引：16

作者：

CARSTENSEN, K

MCFARLANE, ID

RINEHART, KL

HUDMAN, D

SUN, FR

GRIMMELIKHUIJZEN, CJP

机构：

[1] UNIV HAMBURG,CTR MOLEC NEUROBIOL,MARTINISTR 52,W-2000 HAMBURG 20,GERMANY

[2] UNIV HULL,DEPT APPL BIOL,HULL HU6 7RX,N HUMBERSIDE,ENGLAND

[3] UNIV ILLINOIS,SCH CHEM SCI,URBANA,IL 61801

来源：

PEPTIDES | 1993年 / 14卷 / 02期

关键词：

NEUROTRANSMITTER; NEUROHORMONE; PEPTIDE STRUCTURE; MASS SPECTROMETRY; COELENTERATE;

D O I：

10.1016/0196-9781(93)90020-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using a radioimmunoassay against the C-terminal sequence Arg-Pro-NH2 (RPamide) we have isolated the neuropeptide <Glu-Asn-Phe-His-Leu-Arg-Pro-NH2 (Antho-RPamide II) from extracts of the sea anemone Anthopleura elegantissima. Addition of low concentrations of Antho-RPamide II to a tentacle preparation of sea anemones inhibited the spontaneous, rhythmic contractions, suggesting that the peptide is a neurotransmitter or neuromodulator.

引用

页码：131 / 135

页数：5

共 9 条

[1] ISOLATION OF LEU-PRO-PRO-GLY-PRO-LEU-PRO-ARGPRO-NH2 (ANTHO-RPAMIDE), AN N-TERMINALLY PROTECTED, BIOLOGICALLY-ACTIVE NEUROPEPTIDE FROM SEA-ANEMONES [J].