SUCCESSFUL TREATMENT OF REFRACTORY POLYMYOSITIS WITH PULSE INTRAVENOUS CYCLOPHOSPHAMIDE AND LOW-DOSE WEEKLY ORAL METHOTREXATE THERAPY

被引：12

作者：

HIRANO, F

TANAKA, H

NOMURA, Y

MATSUI, T

MAKINO, Y

FUKAWA, E

MIURA, T

MAKINO, I

机构：

[1] Second Department of Internal Medicine, Asahikawa Medical College, Asahikawa

来源：

INTERNAL MEDICINE | 1993年 / 32卷 / 09期

关键词：

AUTOIMMUNE DISEASE; GLUCOCORTICOID THERAPY; IMMUNOSUPPRESSIVE THERAPY; CREATINE KINASE;

D O I：

10.2169/internalmedicine.32.749

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 36-year-old woman gradually developed dysphagia and muscle weakness of the lower extremities. Diagnosis of polymyositis was given from elevation of serum creatine kinase and pathological findings of a muscle biopsy. Despite oral prednisolone and intravenous pulse methylprednisolone therapy, her muscle weakness persisted, and then pulse intravenous cyclophosphamide (IVCY) therapy was initiated and repeated five times in total, which resulted in significant improvement in muscle strength. Thereafter, weekly administration of methotrexate at low dosage further normalized the serum creatine kinase level. We may conclude that IVCY and low-dose weekly methotrexate together could be an alternative in refractory polymyositis.

引用

页码：749 / 752

页数：4

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