BIOCHEMICAL OPENING OF THE BLOOD-BRAIN-BARRIER

被引：55

作者：

BLACK, KL

机构：

[1] Division of Neurosurgery, UCLA School of Medicine, Los Angeles

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1995年 / 15卷 / 1-3期

基金：

美国国家卫生研究院;

关键词：

BLOOD-BRAIN BARRIER; DRUG DELIVERY; LEUKOTRIENE; BRADYKININ; SEROTONIN; HISTAMINE; ARACHIDONIC ACID; BRAIN TUMOR;

D O I：

10.1016/0169-409X(95)00004-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Biochemical agents that can influence the abnormal BBB are reviewed. Vasoactive compounds, including leukotrienes, bradykinin, histamine appear to selectively increase permeability in abnormal brain capillaries. Normal brain capillaries resist the effects of these compounds through an 'enzymatic barrier' that may inactivate vasoactive agents. In contrast, this enzymatic barrier is lost in certain diseased states, allowing vasoactive compounds to selectively increase permeability in abnormal capillaries. Clinically, intracarotid infusion of leukotrienes, bradykinin and other vasoactive agents can increase drug delivery to diseased tissue.

引用

页码：37 / 52

页数：16

共 78 条

[1] DISCRIMINATIVE EFFECT OF GAMMA-GLUTAMYL-TRANSFERASE TRANSPEPTIDASE INHIBITORS ON METABOLISM OF LEUKOTRIENE-C4 IN PERITONEAL-CELLS [J].