SINGLE DOSES OF METHAMPHETAMINE CAUSE CHANGES IN THE DENSITY OF DENDRITIC SPINES IN THE PREFRONTAL CORTEX OF GERBILS (MERIONES-UNGUICULATUS)

被引:28
作者
DAWIRS, RR
TEUCHERTNOODT, G
BUSSE, M
机构
[1] Department of Neuroanatomy, Faculty of Biology, University of Bielefeld
关键词
METHAMPHETAMINE; PREFRONTAL CORTEX; SPINE DENSITY; NEUROPLASTICITY;
D O I
10.1016/0028-3908(91)90155-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Single doses of methamphetamine (25 mg/kg) were administered to adult gerbils. All detectable spines were counted along defined segments of basal, apical and lateral dendrites of Golgi-impregnated pyramidal cells in the medial prefrontal cortex (layers III and V) and the parietal cortex (layer V). These two areas were selected because previous investigations had shown methamphetamine-induced neurotoxicity in prefrontal cortex but not in parietal cortex. The frequencies of dendritic spines in methamphetamine-treated gerbils were found to be significantly increased in the prefrontal cortex, while no significant change was found in the parietal cortex.
引用
收藏
页码:275 / 282
页数:8
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