FAMOTIDINE, THE NEW ANTIULCERO-GENIC AGENT, A POTENT LIGAND FOR METAL-IONS

被引：13

作者：

KOZLOWSKI, H

KOWALIKJANKOWSKA, T

ANOUAR, A

DECOCK, P

SPYCHALA, J

SWIATEK, J

GANADU, ML

机构：

[1] UNIV LILLE 1, CHIM ORGAN & ENVIRONNEMENT LAB, F-59655 VILLENEUVE DASCQ, FRANCE

[2] MED ACAD WROCLAW, DEPT BASIC MED SCI, PL-50367 WROCLAW, POLAND

[3] UNIV SASSARI, DIPARTIMENTO CHIM, I-07100 SASSARI, ITALY

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1992年 / 48卷 / 03期

关键词：

D O I：

10.1016/0162-0134(92)84034-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Potentiometric, polarographic, and spectroscopic results obtained for Cu2+ and Ni2+-famotidine systems clearly indicated that this anti-ulcerogenic drug is a very potent chelating agent able to coordinate cupric ion that was at pH below 2. This drug exhibits excellent histamine H-2 receptor blocking effects and its effective coordination to metal ions may have significant biological implications. Famotidine is found to be a very effective ligand for Ni2+ ions also.

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页码：233 / 240

页数：8

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