EFFECTS OF INTRANASAL VASOPRESSIN AND OXYTOCIN ON PHYSIOLOGICAL RESPONDING DURING PERSONAL COMBAT IMAGERY IN VIETNAM VETERANS WITH POSTTRAUMATIC-STRESS-DISORDER

被引：113

作者：

PITMAN, RK ^{[1
]}

ORR, SP ^{[1
]}

LASKO, NB ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

PSYCHIATRY RESEARCH | 1993年 / 48卷 / 02期

关键词：

STRESS DISORDERS; POSTTRAUMATIC; PSYCHOPHYSIOLOGY; MEMORY; CONDITIONING;

D O I：

10.1016/0165-1781(93)90035-F

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This study measured heart rate, skin conductance, and lateral frontalis electromyographic (EMG) responses in 43 male Vietnam veterans with posttraumatic stress disorder during personal combat imagery. In a double-blind research design, subjects were randomly assigned to receive intranasal arginine vasopressin (20 IU), placebo, or oxytocin (20 IU) an hour before the experiment. The group order of physiologic responding was as predicted: vasopressin > placebo > oxytocin. The most specific effect was exerted by vasopressin on EMG responses. This drug effect was not accounted for by nonspecific changes in responsiveness. Results are consistent with enhancing and inhibiting effects on memory retrieval and conditioned responding of vasopressin and oxytocin, respectively.

引用

页码：107 / 117

页数：11

共 39 条

[1] INTRANASAL OXYTOCIN IN OBSESSIVE-COMPULSIVE DISORDER [J].