ALTERED CYTOKINE EXPORT AND APOPTOSIS IN MICE DEFICIENT IN INTERLEUKIN-1-BETA CONVERTING-ENZYME

被引：1469

作者：

KUIDA, K

LIPPKE, JA

KU, G

HARDING, MW

LIVINGSTON, DJ

SU, MSS

FLAVELL, RA

机构：

[1] VERTEX PHARMACEUT INC, CAMBRIDGE, MA 02139 USA

[2] YALE UNIV, SCH MED, HOWARD HUGHES MED INST, NEW HAVEN, CT 06510 USA

[3] YALE UNIV, SCH MED, IMMUNOBIOL SECT, NEW HAVEN, CT 06510 USA

来源：

SCIENCE | 1995年 / 267卷 / 5206期

关键词：

D O I：

10.1126/science.7535475

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The interleukin-1 beta (IL-1 beta) converting enzyme (ICE) processes the inactive IL-1 beta precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene (ICE(-/-)) did not export IL-1 beta or interleukin-1 alpha (IL-1 alpha) after stimulation with lipopolysaccharide. Export of tumor necrosis factor-alpha and interleukin-6 (IL-6) from these cells was also diminished. Thymocytes from ICE(-/-) mice were sensitive to apoptosis induced by dexamethasone or ionizing radiation, but were resistant to apoptosis induced by Fas antibody. Despite this defect in apoptosis, ICE(-/-) mice proceed normally through development.

引用

页码：2000 / 2003

页数：4

共 42 条

[1] NUCLEOTIDE-SEQUENCE OF HUMAN MONOCYTE INTERLEUKIN-1 PRECURSOR CDNA
AURON, PE
WEBB, AC
ROSENWASSER, LJ
MUCCI, SF
RICH, A
WOLFF, SM
DINARELLO, CA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (24): : 7907 - 7911
[2] ACTIVATION OF INTERLEUKIN-1-BETA BY A CO-INDUCED PROTEASE
BLACK, RA
KRONHEIM, SR
SLEATH, PR
[J]. FEBS LETTERS, 1989, 247 (02) : 386 - 390
[3] BLACK RA, 1988, J BIOL CHEM, V263, P9437
[4] CELL-AUTONOMOUS FAS (CD95) FAS-LIGAND INTERACTION MEDIATES ACTIVATION-INDUCED APOPTOSIS IN T-CELL HYBRIDOMAS
BRUNNER, T
MOGIL, RJ
LAFACE, D
YOO, NJ
MAHBOUBI, A
ECHEVERRI, F
MARTIN, SJ
FORCE, WR
LYNCH, DH
WARE, CF
GREEN, DR
[J]. NATURE, 1995, 373 (6513) : 441 - 444
[5] CARRUTH LM, 1991, J BIOL CHEM, V266, P12162
[6] THE STRUCTURE AND COMPLETE NUCLEOTIDE-SEQUENCE OF THE MURINE GENE ENCODING INTERLEUKIN-1-BETA CONVERTING-ENZYME (ICE)
CASANO, FJ
ROLANDO, AM
MUDGETT, JS
MOLINEAUX, SM
[J]. GENOMICS, 1994, 20 (03) : 474 - 481
[7] THYMOCYTE APOPTOSIS INDUCED BY P53-DEPENDENT AND INDEPENDENT PATHWAYS
CLARKE, AR
PURDIE, CA
HARRISON, DJ
MORRIS, RG
BIRD, CC
HOOPER, ML
WYLLIE, AH
[J]. NATURE, 1993, 362 (6423) : 849 - 852
[8] COHEN JJ, 1984, J IMMUNOL, V132, P38
[9] AUTOCRINE T-CELL SUICIDE MEDIATED BY APO-1/(FAS/CD95)
DHEIN, J
WALCZAK, H
BAUMLER, C
DEBATIN, KM
KRAMMER, PH
[J]. NATURE, 1995, 373 (6513) : 438 - 441
[10] THE INTERLEUKIN-1 FAMILY - 10 YEARS OF DISCOVERY
DINARELLO, CA
[J]. FASEB JOURNAL, 1994, 8 (15) : 1314 - 1325

← 1 2 3 4 5 →