EFFECT OF 6-MERCAPTOPURINE ON SPONTANEOUS CANINE ASTHMA

The responses to 6-mercaptopurine in 2 spontaneously ragweed-sensitive dogs were measured before, during, and after drug therapy. Measurements of skin-sensitizing antibody, response to inhalation challenge, and passive anaphylaxis were made monthly, 2 months prior to drug administration, during the 3 months of therapy, and one month after cessation of therapy. There were no changes in the skin-sensitizing antibody titer. There was partial suppression of passive anaphylaxis. There was a marked inhibition in the production of asthma by direct inhalation challenge. The later response returned to pretreatment levels one month after completion of 6-mercaptopurine administration. © 1969.