益生菌治疗肠易激综合征疗效的Meta分析

被引：0

作者：

赵振飞

机构：

[1] 新疆医科大学

关键词：

肠易激综合征; 有益菌种; 随机对照试验; Meta分析; 腹痛;

D O I：

暂无

年度学位：

2014

学位类型：

硕士

导师：

摘要：

目的：探讨益生菌治疗肠易激综合征(IBS)的临床疗效及安全性。方法：计算机检索PubMed.国际Cochrane中心、Embase.中国生物医学文献数据库、中国期刊全文数据库、万方数据库、维普数据库,收集益生菌治疗IBS的随机对照试验(RCT),并手工检索已获文献的参考文献,由两位评价者按照纳入和排除标准筛选、提取资料并行方法学质量评价,采用RevMan5.0软件对数据行Meta分析。结果：共纳入19个RCT,2172例患者,Meta分析结果显示：益生菌较安慰剂在改善患者总体症状积分[SMD=-0.18,95%CI(-0.28,-0.08),P=0.0006]、腹痛[SMD=-0.13,95%CI(-0.21,-0.04),P=0.003]、腹胀[SMD=-0.15,95%CI(-0.25,-0.05), P=0.004]、排便不适感[SMD=-0.15,95%CI(0.27,-0.02),P=0.02]方面均有显著意义,在总体生活质量[SMD=0.09,95%CI(-0.08,0.25),P=0.30]、不良反应发生率[RR=0.91,95%CI(0.71,1.16),P=0.45]方面无显著意义。结论：目前证据显示益生菌制剂能有效改善IBS患者的临床症状,且安全性好,但现有RCT在力法质量学以及研究设计上存在一定不足,今后的研究应在菌株、剂量、疗程、IBS亚组患者方面进行严谨、高质量、大样本长期随访的临床研究予以证实。

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