小鼠模型在哮喘中的研究进展

被引：0

作者：

郭其苗

机构：

[1] 华中科技大学

关键词：

小鼠哮喘模型; 哮喘; 卵清蛋白;

D O I：

暂无

年度学位：

2010

学位类型：

硕士

导师：

刘光辉;

摘要：

哮喘是人类的常见病和多发病,但病因和发病机制很复杂,至今还不是很清楚。由于人体试验的局限性,所以对哮喘的研究多采用动物模型。学者们对小鼠的免疫学和遗传学研究的已经非常清楚,可以利用的试剂和实验技术也相对较多,小鼠与其他动物相比具有无可比拟的优势。小鼠的哮喘模型应用非常广泛,对促进人类对哮喘的研究做出了巨大贡献。但是小鼠毕竟和人类有着本质的区别,所以本文就小鼠哮喘模型在体现人类哮喘的特征性方面的优缺点进行总结分析,使人们对这一模型进行正确认识,并在将来更好的利用它为人类服务。

引用

页数：30

共 16 条

[1]

Modulation of airway hyperresponsiveness and eosinophilia by selective histamine and 5‐HT receptor antagonists in a mouse model of allergic asthma.[J].J J.De Bie;P A J.Henricks;W W.Cruikshank;GHofman;E H.Jonker;F P.Nijkamp;A J M.Van Oosterhout.British Journal of Pharmacology.2009, 5

[2]

IgE — a marker of late asthmatic response?.[J].K. S.Babu;S. H.Arshad.Clinical & Experimental Allergy.2008, 2

[3]

Ovalbumin‐sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation.[J].G. R.Zosky;A. N.Larcombe;O. J.White;J. T.Burchell;T. Z.Janosi;Z.Hantos;P. G.Holt;P. D.Sly;D. J.Turner.Clinical & Experimental Allergy.2007, 5

[4]

Building a better mouse model: experimental models of chronic asthma [J].

Fulkerson, PC ;

Rothenberg, ME ;

Hogan, SP .

CLINICAL AND EXPERIMENTAL ALLERGY, 2005, 35 (10) :1251-1253

[5]

Effect of GM-CSF on immune, inflammatory, and clinical responses to ragweed in a novel mouse model of mucosal sensitization [J].

Cates, EC ;

Gajewska, BU ;

Goncharova, S ;

Alvarez, D ;

Fattouh, R ;

Coyle, AJ ;

Gutierrez-Ramos, JC ;

Jordana, M .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 111 (05) :1076-1086

[6]

Elicitation of the allergic reaction in β-lactoglobulin-sensitized Balb/c mice:: biochemical and clinical manifestations differ according to the structure of the allergen used for challenge [J].

Adel-Patient, K ;

Nahori, MA ;

Proust, B ;

Silva, JRLE ;

Créminon, C ;

Wal, JM ;

Vargaftig, BB .

CLINICAL AND EXPERIMENTAL ALLERGY, 2003, 33 (03) :376-385

[7]

Molecular and cellular mechanisms of allergic disease [J].

Broide, DH .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (02) :S65-S71

[8]

Innervation of the airways: introduction.[J].Brendan J. Canning.Respiration Physiology.2001, 1

[9]

Aspirin and asthma [J].

Babu, KS ;

Salvi, SS .

CHEST, 2000, 118 (05) :1470-1476

[10]

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils; airway hyper-responsìveness; and the late asthmatic response.[J].Margaret J Leckie;Anneke ten Brinke;Jamey Khan;Zuzana Diamant;Brian J O'Connor;Christine M Walls;Ashwini K Mathur;Hugh C Cowley;K Fan Chung;Ratko Djukanovic;Trevor T Hansel;Stephen T Holgate;Peter J Sterk;Peter J Barnes.The Lancet.2000, 9248

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