N-乙酰半胱氨酸对高血压心脏重构的影响

被引：0

作者：

李小波

机构：

[1] 南京医科大学

关键词：

N-乙酰半胱氨酸; 谷胱甘肽; 高血压; 心脏重构;

D O I：

暂无

年度学位：

2007

学位类型：

硕士

导师：

陈绍良;

摘要：

目的探讨N-乙酰半胱氨酸(NAC)对高血压大鼠心脏重构的影响及其作用机理。方法结扎SD大鼠腹主动脉造成高血压模型，随机分为四周组及八周组，前者再次随机分为手术组及非手术组，而后者进一步随机分为手术组、非手术组及手术+NAC组(NAC 75mg／d，共4周)。两组大鼠分别于四周及八周时分别测定心脏功能、颈动脉血压、左室质量，观察心脏组织中还原型谷胱甘肽及基质金属蛋白酶(MMP)-2和MMP-9的分布，并测定心脏组织胶原含量的变化。结果与手术组相比，手术+NAC组大鼠收缩压明显降低[(161±6)vs(198±10)mmHg，P＜0.05]、左心室收缩功能明显改善[EF(77.2±6.4)％vs(90.6±2.7)％，SF(56.53±4.37)％vs(41.02±5.84)，P均＜0.05]、心肌组织中还原型谷胱甘肽的含量显著增加[(84.5±7.1)％vs(38.6±3.4)％P＜0.05]，而左室质量(1.33±0.05 vs 1.46±0.1g，P＜0.05)及心肌组织中的基质金属蛋白酶分布均显著降低[MMP-2(56.9±6.1)％vs(96.8±4.8)％，P＜0.05；MMP-9(43.7±8.1)％vs (90.6±6.7)％]、心肌胶原含量明显减少。结论N-乙酰半胱氨酸通过增加心肌组织还原型谷胱甘肽含量，改善心肌组织氧化还原状态，从而减缓高血压大鼠心脏的进一步重构。

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