双心汤治疗稳定型冠心病合并抑郁的临床研究

被引：0

作者：

彭金祥

机构：

[1] 南京中医药大学

关键词：

双心汤; 稳定型冠心病; 抑郁; 疏肝解郁;

D O I：

暂无

年度学位：

2011

学位类型：

硕士

导师：

姚祖培;

摘要：

目的：观察中药双心汤治疗稳定型冠心病胸痛患者合并抑郁情志障碍的临床疗效,探讨疏肝解郁、调和气血法对治疗稳定型冠心病合并抑郁的有效性。方法：选取稳定型冠心病胸痛合并抑郁情志障碍患者60例,随机分为治疗组30例和对照组30例。治疗组在常规抗心肌缺血治疗及心理疏导的基础上服用双心汤,连用4周；对照组仅采用常规抗心肌缺血治疗及心理疏导,连续4周。对两组患者胸痛症状积分变化和总有效率、Zung抑郁自评量表评分变化和减分率、中医证候积分变化和总有效率进行疗效对照观察并统计分析。结果：治疗后,中药治疗组疗效明显优于对照组：治疗组胸痛症状积分降低显著优于对照组(P<0.05),总有效率80%,与对照组(23.33%)比较有显著性差异(P<0.05)；Zung抑郁自评量表评分减少显著优于对照组(P<0.05),减分总有效率76.67%,与对照组(26.67%)比较差异有统计学意义(P<0.05)；中医症候积分降低显著优于对照组(P<0.05),总有效率83.33%,比较对照组(26.67%)有统计学意义(P<0.05)。治疗后两组平均心率均有所减少,而治疗组疗效明显优于对照组(P<0.05)；治疗后两组血糖、血脂水平虽无显著性差异(P>0.05),但治疗组血糖、血脂水平均呈现下降趋势：治疗后两组患者血常规、尿常规、粪常规以及肝肾功能均未出现异常。结论：双心汤能有效减轻和解除稳定型冠心病合并抑郁患者的胸痛症状,同时显著改善患者的焦虑、抑郁情绪及整体中医症候。提示中医疏肝解郁、调和气血法对临床胸痛伴抑郁而常规抗心肌缺血治疗乏效的稳定型冠心病是一个值得重视的有效疗法。

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