纳米羟基磷灰石/胶原复合生物材料的制备与碳化二亚胺交联改性研究

被引：0

作者：

周金敏

机构：

[1] 吉林大学

关键词：

纳米羟基磷灰石; 胶原; 复合材料; 碳化二亚胺;

D O I：

暂无

年度学位：

2009

学位类型：

硕士

导师：

马宁;

摘要：

羟基磷灰石和胶原是人和脊椎动物骨骼中主要的无机和有机成分,都具有良好的生物性能,已经广泛地应用于牙周组织再生领域。由于单一使用时具有不同的缺陷,故有必要将二者联合制备复合生物材料以实现材料的优势互补。本论文根据骨仿生合成的原理,采用原位合成法制备纳米羟基磷灰石/胶原复合生物材料并进行碳化二亚胺交联改性的研究。利用十二烷基磺酸钠-聚丙烯酰胺凝胶电泳和红外光谱分析表明,从牛跟腱采用乙酸溶解-胃蛋白酶消化和分级沉淀的方法提取的提取物为Ⅰ型胶原,且很好地保持了Ⅰ型胶原的三股螺旋结构;通过X射线衍射、扫描电镜观察、红外光谱和热重分析对纳米羟基磷灰石/胶原复合材料进行结构、表观形貌和组成的表征,探讨了制备纳米羟基磷灰石/胶原复合材料仿生合成的机理;通过红外光谱、差示扫描量热分析、溶胀率和抗体外胶原酶降解情况分析交联的效果,研究交联条件对碳化二亚胺交联纳米羟基磷灰石/胶原复合材料性能的影响,探讨了交联机理,为复合材料的制备和交联改性提供理论基础。

引用

页数：48

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