THE EXPRESSION OF GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR IN ACTIVATED MOUSE LYMPHOCYTES DECLINES WITH AGE

被引：19

作者：

CAI, NS ^{[1
]}

LI, DD ^{[1
]}

CHEUNG, HT ^{[1
]}

RICHARDSON, A ^{[1
]}

机构：

[1] ILLINOIS STATE UNIV,DEPT CHEM,NORMAL,IL 61761

来源：

CELLULAR IMMUNOLOGY | 1990年 / 130卷 / 02期

关键词：

D O I：

10.1016/0008-8749(90)90274-U

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The expression of granulocyte/macrophage colony-stimulating factor (GM-CSF) was studied in spleen lymphocytes isolated from male C57BL/6J mice of 6, 20, and 29 months of age. GM-CSF expression (biological activity and mRNA level) was maximum after culturing the lymphocytes for 45 hr with concanavalin A and phorbol myristate acetate. The induction of both GM-CSF activity and mRNA levels was observed to decline over 60% between 6 and 29 months of age. The age-related decline in the level of GM-CSF paralleled the age-related decline in the mRNA levels of interleukin-2 and interleukin-3. © 1990.

引用

页码：311 / 319

页数：9

共 47 条

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